Entire-body PET Scans for Multiple Sclerosis
Exploratory Study of Entire-body PET Scans for Multiple Sclerosis
  • Phase

    Early Phase 1
  • Study Type

  • Status

  • Study Participants

To evaluate whether an entire-body positron emission tomography (PET) scanner can be exploited to improve evaluation, monitoring and measurement of both peripheral and central demyelination in multiple sclerosis (MS) patients.
To collect exploratory data using the most recent PET-CT scanners with their increased detection sensitivity and spatial resolution for the evaluation of F18-florbetapir radiopharmaceutical uptake in the nervous system of the entire body with special attention to correlation of radiotracer activity levels in the myelinated, demyelinated, or remyelinated white matter of multiple sclerosis (MS) patients compared to normal healthy subjects. The pilot study will be conducted on 20 participants as a clinical research trial of PET amyloid and myelin imaging with the primary objective of identifying possible differences in F18-florbetapir radiotracer activity for MS patients compared to normal healthy subjects, and the secondary objective of monitoring psychological health of those participants who elect to be informed of imaging results and who complete a panel of psychometric scales before and after imaging results disclosure.
Study Started
Sep 01
Primary Completion
Mar 31
Study Completion
Sep 01
Last Update
Sep 06

Diagnostic Test Entire-body PET-CT scans

Entire-body PET-CT scans will be performed with state-of-the-art scanners with different manufacturers' models including Siemens Biograph Vision, United Imaging uEXPLORER and possibly other recently FDA-approved PET-CT scanners.

Drug Amyvid radiopharmaceutical

Amyvid (F18-florbetapir) will be evaluated for binding to white matter of the peripheral and central nervous system of participants

Siemens Biograph Vision PET-CT scans Other

Parallel study arms defined by PET-CT scanners by different manufacturer and model

United Imaging uEXPLORER PET-CT scans Other

Parallel study arms defined by PET-CT scanners by different manufacturer and model


Inclusion Criteria:

Multiple sclerosis (MS) patients with advanced state of the disease as evidenced by severe disability scores (EDSS > 5) with impaired motor control of extremities.
Normal healthy subjects.
Willing and able to lie motionless on the PET-CT scanner bed for at least 10 minutes and up to 20 minutes for the duration of the PET-CT medical imaging scan.

Exclusion Criteria:

Any additional complicating medical illness other than MS including any other neuropsychiatric illness unrelated to MS diagnosed prior to the onset of initial symptoms of MS.
Pregnancy or breast feeding.
Diabetes or other metabolic-endocrine disorders.
Any known concomitant acute infection.
History of metastatic or locally invasive cancer.
Recent surgery, chemotherapy or radiation therapy.
No Results Posted