Title
Ferritin Screening And IRon Treatment for Maternal Anemia and FGR Prevention Trial
Ferritin Screening And IRon Treatment for Maternal Anemia and Fetal Growth Restriction (FGR) Prevention - a Multi Centre Randomised Controlled Trial (RCT)
Phase
Phase 4Lead Sponsor
Services Institute of Medical Sciences, PakistanStudy Type
InterventionalStatus
Unknown statusIndication/Condition
Iron Deficiency (Without Anemia) Pregnancy RelatedIntervention/Treatment
Parentral IronStudy Participants
600Prevalence of anemia in Asia is more than 50%. All woman who book for antenatal care with non-anaemic iron deficiency (NAID) can be offered therapeutic doses of parentral iron, as a directly observed complete therapy, to prevent of maternal anaemia and fetal growth restriction. The investigators will compare this intervention with usual care in a multicentre randomised trial.
Prevalence of anemia (haemoglobin less than 11 gm/dl) in Asia is more than 50% and non-anaemic iron deficiency (ferritin less than 30 microgm/l) or NAID is likely to be more prevalent than this figure. It has been hypothesised that NAID in pregnancy can be linked to maternal fatigue and anaemia, and infant birth weight and growth restriction. The investigators will compare, in NAID, active intervention (therapeutic doses of parentral iron, as a directly observed complete therapy, to replenish iron stores) vs usual care (prophylactic oral iron supplementation) to prevent of maternal anaemia and fetal growth restriction in a multicentre randomised trial.
Correction of Iron stores without anaemia
Intravenous Iron to correct Iron deficiency without anaemia
Usual antenatal care
Inclusion Criteria: Non-anaemic iron deficiency Exclusion Criteria: Anaemia or normal iron stores
