Effects of Gum Arabic Supplementation in Hemodialysis Patients
Study of Some Pharmacological and Biochemical Effects of Gum Arabic Supplementation to Hemodilaysis Patients
Lead SponsorUniversity of Khartoum
Indication/ConditionKidney Failure, Chronic
Intervention/TreatmentGum Arabic ...
Gum Arabic is a naturally produced gummy exudate from Acacia Senegal tree. It's a complex polysaccharide with proven prebiotic properties. Through its effect on intestinal bacteria, it's expected to reduce systemic levels of toxic bacterial metabolites and reduce inflammatory markers.By increasing fecal bacteria mass it's also expected to reduce blood urea level. These changes are potentially beneficial to hemodialysis patients who suffer from disturbed intestinal flora and a chronic inflammatory status. The investigators hypothesize that supplementing the diet of hemodialysis patients with Gum Arabic for four weeks would reduce inflammatory markers, increase total anti-oxidant capacity and reduce blood urea concentration.
Instantly soluble granules of Gum Arabic; 100% Acacia Senegal
Maltodextrin powder, easily soluble
Patients will receive 10 g of Gum Arabic supplementation daily for four weeks. Gum Arabic is provided in the form of easily soluble granules. Participants are asked to dissolve it in water or juice and drink it.
Patients will receive 5 g of maltodextrin supplementation daily for four weeks. Maltodextrin is an easily digested polysacharide provided in the form of soluble whitish powder that has no taste or odor. Participants are asked to dissolve it in water or juice and drink it.
Patients will receive 20 g of Gum Arabic supplementation daily for four weeks
Patients will receive 40 g of Gum Arabic supplementation daily for four weeks
Inclusion Criteria: Adult end-stage renal disease patients maintained on regular hemodialysis Exclusion Criteria: Chronic liver disease Malignant condition Inflammatory bowel disease History of bowel resection Long term antibiotic therapy Pregnancy or lactation Current use of immunosuppressive medication