Title

Different Kinds of Acupuncture Treatment for Knee Osteoarthritis
Different Kinds of Acupuncture Treatment for Knee Osteoarthritis:a Multicentre Randomised Controlled Trial
  • Phase

    N/A
  • Study Type

    Interventional
  • Status

    Active, not recruiting
  • Intervention/Treatment

    Celebrex ...
  • Study Participants

    360
Knee osteoarthritis (KOA) a chronic disease with symptoms of persistent pain or rest pain , joint stiffness, numbness, limitation of activity and even disability, with significant associated costs and effects on individuals' life quality. Acupuncture as an approach for the management of chronic pain, is receiving increasing recognition from both the public and professionals. The aim of this study is to indicate the effects of three commonly used acupuncture treatments for KOA.
360 subjects with KOA recruited from six centers will be randomized to six groups ,and receive four-week acupuncture, Electro-acupuncture, Moxibustion ,Warm-needling ,sham-needle, celebrex treatment. The primary outcomes are Visual Analogue Scale (VAS) and WOMAC function score.The Secondary outcomes are WOMAC pain score, WOMAC stiffness score,the Physical Activity Scale of the Elderly (PASE),knee joint swelling measurement and WHO-BREF life quality scale.The follow-up period is six months. This study will be a rigorous,randomized, sham and drug controlled trial focusing on using different kinds of acupuncture treatment for treating KOA.
Study Started
Jun 24
2018
Primary Completion
Dec 31
2022
Anticipated
Study Completion
Dec 31
2022
Anticipated
Last Update
Mar 10
2022

Other treatment1

Acupoints:Liangqiu(ST34),Xuehai(SP10),Neixiyan(EX-LE4),Dubi(ST35),Yanglingquan (GB34)and Yinlingquan (SP9) operation: the needles will be manipulated using techniques including lifting, thrusting, twisting, and rotating, until De Qi is achieved for 30 minutes.

Other treatment2

Acupoints:Needling points are the same to the above group operation: The electrode will be connected Neixiyan (EX-LE4) and Dubi (ST35) and electrode wire will be connected to the electro-acupuncture apparatus using dilatational wave with a frequency of 2/100 Hz, the current intensity is within participants'tolerance, for 30 minutes.

Other treatment3

Acupoints:treating points are the same to the above group Operation: During treatment, participants will choose to sit with knee buckling natural 90 degrees ,with the affected knee(s) exposed. Mild moxibustion are applied at the distance of 2-3 cm away from the skin of both the Neixiyan (EX-LE4) and Dubi (ST35) for 30 minutes.

Other treatment4

Acupoints:Needling points are the same to the above group Operation: Warm-needling acupuncture are applied at both Neixiyan (EX-LE4) and Dubi (ST35). That is to insert one zhuang(about 2cm)of Huai Qing Ai on the top of the needle, and burn the moxa at the lower end ,each acupoint applied 2 Zhuang for 30 minutes.

Other treatment5

points:Sham Liangqiu(ST34),Sham Xuehai(SP10), Sham Neixiyan(EX-LE4), Sham Yanglingquan(GB34),Sham Yinlingquan (SP9) Operation: Sham acupuncture with non-meridian and non-acupoint needling method, respectively acupuncture 1cm away lateral to the above sham acupoints with a 0.18 * 25mm single-use needle with the depth of 1-2mm.

Drug Celebrex

Drug: Celebrex (Celebrex, Capsules, Pfizer Pharmaceuticals Ltd), which will be applied 1 time daily( taken 0.2g one time orally ) Time of treatment :4 weeks Other Name: celecoxib

Acupuncture group Experimental

When recruited from six centers,the participant will be randomized to six groups .In acupuncture group participant will receive four-week acupuncture treatment(three times a week )continuously for 4 weeks,12 treatments in total. The follow-up period is six months.

Electro-acupuncture group Experimental

When recruited from six centers,the participant will be randomized to six groups. In this group participant receive four-week electro-acupuncture treatment(three times a week )continuously for 4 weeks,12 treatments in total. The follow-up period is six months.

Moxibustion group Experimental

When recruited from six centers,the participant will be randomized to six groups. In this group participant receive four-week moxibustion treatment (three times a week )continuously for 4 weeks,12 treatments in total. The follow-up period is six months.

Warm-needling group Experimental

When recruited from six centers,the participant will be randomized to six groups. In this group participant receive four-week warm-needling treatment (three times a week )continuously for 4 weeks,12 treatments in total. The follow-up period is six months.

Sham-needle group Sham Comparator

When recruited from six centers,the participant will be randomized to six groups.In this group participant receive four-week sham acupuncture treatment (three times a week )continuously for 4 weeks,12 treatments in total. The follow-up period is six months.

Celebrex group Active Comparator

When recruited from six centers,the participant will be randomized to six groups . In this group participant will receive Celebrex (Celebrex, Capsules, Pfizer Pharmaceuticals Ltd)treatment, which will be applied 1 time daily(one time oral 0.2g) for 4 weeks. The follow-up period is six months.

Criteria

Inclusion Criteria:

Meet the Clinical Classification Criteria for Osteoarthritis of the Knee, diagnosed by specialist.
Aged 40-75 years old;
History of chronic knee pain for more than 3 months, and complain of knee pain on most days of the past month;
Kellgren and Lawrence Grades 1-3;
With related knee pain in one or both knees rated > 4 cm on a 10 cm Visual Analog Scale(VAS) (VAS:0 to 10)
Who volunteer to participate and sign the consent form .

Exclusion Criteria:

Knee osteoarthritis patients with gout, infection, tumor, autoimmune diseases, trauma or other causes of knee pain or knee deformities;
Patients who have local skin damage, poor skin conditions or coagulant dysfunction and patients who are not suitable for acupuncture;
Patients who are accompanied with serious medical problems or mental disorders, cognitive dysfunction,disorders of shallow sensation or who cannot cooperate with the treatment;
Patients who have received acupuncture or needle knife in the past month;
Other patients who are not suitable for acupuncture treatment.
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