Trial | NCT03225456  Report issue

Title

Oxytocin and Eating
Exploring the Effects of Oxytocin on Appetite Regulation in Healthy Adult Men

  • Phase

    Phase 2

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    60
In this protocol, the investigators propose a randomised controlled trial to explore the effects of intra-nasal oxytocin administration on appetite regulation. The investigators will run a cross-over design with 60 healthy adult men.
Study Started
Sep 30
2017
Anticipated
Primary Completion
Dec 31
2018
Anticipated
Study Completion
Jan 31
2019
Anticipated
Last Update
Jul 21
2017

Drug Syntocinon

Intra-nasal oxytocin

Drug Placebos

Intra-nasal placebo

Oxytocin Experimental

Participants will receive two doses of 24 IU intra-nasal oxytocin (Syntocinon) in a single session

Placebo Placebo Comparator

Participants will received match placebo, again in two doses in a single session

Criteria 

Inclusion Criteria:

Gender: Male
Age: 21-45 years
Normal weight: Body mass index of 18.5 to 22.9
Have had a stable weight for the past 3 months (less than 5kg)
Have regular breakfast meals (≥ 4 times a week of self-reported consumption of a breakfast meal)
Have habitual sleep of 6.5-8.5 hours
Have English as first language (or fluent in spoken and written English)

Exclusion Criteria:

Symptoms / history of any major medical condition, including:

Bariatric surgery or surgical obesity treatment
Diabetes
Cardiovascular disease
Thyroid disease
Anaemia
Psychiatric disorders
Eating disorders
Excessive exercise (running > 40 km or exercising > 10 hr in a week)
Currently on a special diet or trying deliberately to restrict food intake
Currently on a weight loss program
Smoking or substance abuse
Use of medications that can affect weight (e.g., steroids, approved weight-loss drugs)
No Results Posted