Endoscopic Assessment and Prediction of Microbiome-modifying Interventions
Lead SponsorTel Aviv University
Indication/ConditionGut Microbiome Antibiotic Side Effect
The investigators would like to examine the extent of gut microbiome rehabilitation in healthy people after the consumption of antibiotics.
Outcomes of probiotic treatment versus bacteriotherapy will be compared.
The investigators would like to examine the extent of rehabilitation of the composition and functioning of the intestinal bacteria in healthy people after the consumption of antibiotics.
Since the digestive mocus enables the connection between the host and the bacteria that live within it, the investigators would like to characterize the microbiome in the different areas along the digestive system - before antibiotic treatment and after rehabilitation by probiotic treatment versus bacteriotherapy.
4 weeks of probiotic treatment after 7 days of antibiotics (Metronidazole+Ciprofloxacin)
Bacteriotherapy (autologous fecal microbiota transplantation) after 7 days of antibiotics (Metronidazole+Ciprofloxacin)
No intervention after antibiotic treatment.
Probiotic treatment after antibiotic treatment.
Bacteriotherapy after antibiotic treatment.
Inclusion Criteria: Healthy volunteers Age: 18 years and up Gender: women and men Exclusion Criteria: Pregnancy Age under 18 years antibiotic treatment 3 months prior to enrollment Viral Hepatitis HIV positive