Hypnotic Intake and Motor and Cognitive Performances at High Altitude
The Effect of Acute Hypnotic Intake Before a Night at High Altitude on Cognitive and Motor Performances
This study aims to determine the effect of acute hypnotic intake (Zolpidem) on sleep, cognitive and motor performances and on acute mountain sickness symptoms at high altitude. Healthy subjects will be evaluated on 4 occasions (twice at sea level and twice at high altitude), after hypnotic or placebo intake. Following an early wake-up (01:00), symptoms, cognitive and motor performances will be assessed to determine potential residual effects of Zolpidem within such conditions.
The hypnotic will be administrated orally at 22:00 in the evening before a sleep recording and an early wake-up at 01:00 for cognitive and motor assessment.
The placebo will be administrated orally at 22:00 in the evening before a sleep recording and an early wake-up at 01:00 for cognitive and motor assessment.
Acute zolpidem intake at sea level
Acute placebo intake at sea level
Acute zolpidem intake at high altitude
Acute placebo intake at high altitude
Inclusion Criteria: No sojourn above 2500 m during the past 2 months Coffee intake < 3 cups per day Non-smoker Exclusion Criteria: Respiratory, cardiovascular, metabolic or neuromuscular diseases Psychiatric disorders Use of hypnotics within the past year Dependence syndrome (alcool, drugs, etc) Severe insomnia or somnolence