Medium Chain Triglycerides and Brain Metabolism in Alzheimer's Disease
Proof of Concepts: Can a Supplement Ketogenic Based MCT Oil Increases Cerebral Capture Ketones in People With Alzheimer's Disease?
Lead SponsorUniversity of Sherbrooke
StatusCompleted No Results Posted
Intervention/Treatmentmedium chain triglyceride ...
Evaluate and compare the changes in brain ketone and glucose uptake after taking two different MCT oil emulsions (60-40 oil or C8 oil) for one month, in a group of people with Alzheimer's disease and a control group.
Based on a PET/MRI protocol, the aim of this study is to evaluate and compare the response to the dietary supplementation of two different MCT oils (60% C10 + 40% C8 or 100 % C8) in two groups, patients with Alzheimer's disease and healthy elderly people (N=10/group). After a baseline evaluation, participant will test one of the supplements during two successive periods of one month; each period of time ending with 18F-FDG and 11C-acetoacetate PET scans.
1-month supplementation of 30 g MCT oil (60% C10 + 40% C8)/day
1-month supplementation of 30 g MCT oil (100% C8)/day (1-month of C8 MCT oïl)
Patients with mild Alzheimer's disease. 1-month of 60-40 MCT oil and 1-month of C8 MCT oil (order of the two intervention are randomized)
Healthy elderly people 1-month of 60-40 MCT oil and 1-month of C8 MCT oil (order of the two intervention are randomized)
Inclusion Criteria: Good general health for Control group Diagnosis of Alzheimer's disease (NINCDS-ADRDA criteria) for AD group Exclusion Criteria: Depression Medical or psychiatric conditions that could interfere with study participation Fasting plasma glucose ≥7.0 mM (diabetes or prediabetes) Already on MCT supplementation Clinically-significant gastrointestinal disease/conditions Clinically-significant liver disease/dysfunction Clinically-significant renal disease/dysfunction Clinically-significant cardiac disease/conditions Hypertension Uncontrolled dyslipidaemia Vitamin B12 deficiency Structured physical activity (more than 3 times/week)