Bispectral Index Under Propofol Anesthesia in Children : a Study Between TIVA and TCI
Bispectral Index Under Propofol Anesthesia in Children : a Comparative Randomised Study Between TIVA and TCI
Lead SponsorAPHP - Hôpital Necker
StatusCompleted No Results Posted
Intervention/Treatmentpropofol remifentanil ...
In children, only a few studies have compared different modes of propofol infusion during a total intravenous anesthesia (TIVA) with propofol and remifentanil. The aim of this study is to compare Bispectral Index (BIS) profiles (percentage of time spent at adequate BIS values) between four modes of propofol infusion: titration of the infusion rate on clinical signs (TIVA0), titration of the infusion rate on the BIS (TIVABIS), target controlled infusion (TCI) guided by the BIS either with the Kataria model (TCI KBIS) or the Schnider model (TCI SBIS).
Methods: Children will be prospectively randomized into the 4 groups. In the TIVA0 group the anesthesiologist is blinded to the BIS. In each group, the percentage of time with adequate BIS values (45-55), the bias and imprecision will be calculated.
Target controlled infusion using schnider model for propofol
Target controlled infusion using Kataria model for propofol
Total intravenous anesthesia without use of a pharmokinetic model
Maintaining a bispectral index between 45 and 55
Remifentanil at discretion of the anesthesiologist
Propofol : TIVA guided by clinical signs. Remifentanil
propofol : TIVA guided by EEG Monitoring. Remifentanil
Propofol : TCI Kataria guided by EEG Monitoring. Remifentanil.
Propofol : TCI Schnider guided by EEG Monitoring. Remifentanil.
Inclusion Criteria: weighting more than 15 kg; American Society of Anesthesiologists physical status I or II scheduled for middle ear surgery Exclusion Criteria: cardiovascular, neurological, hepatic or renal impairment, if their body mass index was above 95th percentile or if they received any drug interfering with the central nervous system.