Creatine for Depressed Male and Female Methamphetamine Users
An Open-Label Pilot Study of Creatine for Depressed Male and Female Methamphetamine Users
  • Phase

    Phase 3
  • Study Type

  • Status

    Unknown status
  • Intervention/Treatment

    creatine ...
  • Study Participants

Assess the antidepressant/anxiolytic effect of creatine in male and female methamphetamine users
Assess creatine's effect on methamphetamine use
Assess the safety of creatine in male methamphetamine users with depression
Study Started
Nov 30
Primary Completion
Oct 31
Study Completion
May 31
Last Update
Dec 11

Drug Creatine monohydrate

  • Other names: Creapure

Creatine monohydrate Experimental

5 grams of daily creatine monohydrate by mouth for 8 weeks


Inclusion Criteria:

Current primary diagnosis of methamphetamine dependence or abuse, with methamphetamine preferred drug of abuse
Current diagnosis of major depressive disorder (primary or substance-induced)
Current diagnosis of an anxiety disorder (primary or substance-induced)
Current Hamilton Depression Rating scale score > or = to 16
Current Hamilton Anxiety Scale score > = to 18
If taking a psychotropic medication for depressed or anxious mood, regimen must be stable for > = to 4 weeks prior to creatine treatment initiation

Exclusion Criteria:

Persons unable to provide adequate informed consent
Persons who are at clinically significant suicidal or homicidal risk
Primary substance-related diagnosis other than methamphetamine dependence or abuse
Positive pregnancy test (females only)
History of renal disease
Clinically significant medical or neurological illness identified by history, physical exam and laboratory testing
History of hypersensitivity reaction to creatine
No Results Posted