Microdrilling Surgery for Full Thickness Chondral Lesions of the Knee Augmented With Concentrated Bone Marrow Aspirate, Platelet Rich Plasma and Hyaluronic Acid
Lead SponsorBone and Joint Clinic of Baton Rouge
StatusCompleted No Results Posted
Intervention/Treatmentplatelet-rich plasma hyaluronic acid allogeneic bone marrow ...
This study seeks to evaluate a treatment for multiple full thickness chondral lesions in the knee. Eligible subjects will undergo a microdrilling surgery and up to 12 post operative intra-articular injections of bone marrow aspirate concentrate (BMAC), platelet rich plasma (PRP) and hyaluronic acid (HA).
All patients will undergo an arthroscopic surgical procedure in which small holes are drilled throughout the areas of damaged cartilage (standard of care)
All patients will receive up to 12 post-operative intra-articular knee injections of BMAC (derived from iliac crest), PRP (derived from peripheral blood) and HA (Supartz)
Inclusion Criteria: MRI-confirmed full-thickness unipolar or bipolar chondral lesion(s) from osteoarthritis. Exclusion Criteria: Inflammatory arthritis Body mass index (BMI) greater than 35 Presence of significant varus or valgus knee instability or unusually stiff knee Greater than 50% deviation of the mechanical axis Presence of active cardiac disease Presence of active pulmonary disease Prior septic arthritis of the involved joint Presence of active bacterial or Mycobacterial infection Presence of a known hypercoagulable state Pregnant or lactating females Subject known to be positive for hepatitis B, hepatitis C, or HIV Known allergy to hyaluronic acid Patients who are unable or unwilling to participate fully in post-operative physical therapy Patients with a contraindication to MRI scanning Any disorder that compromises ability to give consent or comply with study procedures Patients who are felt to be at significantly increased risk for elective orthopedic surgery Non-ambulatory patients Patients with cognitive impairment