Anesthetic Blockades and Migraine
Effects of Anesthetic Blockades on Pain Modulation in Migraine
  • Phase

    Phase 2
  • Study Type

  • Status

    Completed No Results Posted
  • Study Participants

Greater occipital nerve (GON) anesthetic blockades are widely used for the treatment of headaches, yet its efficacy in migraine has hardly been assessed with controlled studies. The aim of this study is to evaluate the short-term clinical efficacy of GON anaesthetic blockades in chronic migraine and to analyze their effect on pressure pain thresholds (PPTs) in different areas. We hypothesize that those patients receiving real GON anesthetic blockade will receive greater improvements in pain nociception. We will conduct a double-blind, randomized, parallel and placebo-controlled clinical trial where one group will be treated with bilateral GON blockade with bupivacaine 0,5% and the other group will be treated with placebo.
Study Started
Jul 31
Primary Completion
Jan 31
Study Completion
Jan 31
Last Update
Jan 05

Drug Anesthetic blockades with bupivacaine

Drug Isotonic saline injection

Anesthetic blockades with bupivacaine Experimental

Patients will receive a bilateral greater occipital nerve blockade with bupivacaine 0,5%

Isotonic saline injection Placebo Comparator

Patients will receive a bilateral occipital injection with isotonic saline


Inclusion Criteria:

Chronic migraine

Exclusion Criteria:

Other primary headaches
Other secondary headaches
Co-morbid medical diseases
No Results Posted