Cortical Representation of Hyperalgesia Induced by Nerve Growth Factor
Cortical Representation of NGF-induced Hyperalgesia
Intraepidermal injection of nerve growth factor results in a non-inflammatory hyperalgesia for thermal and mechanical stimuli. This hyperalgesia is similar to the pathological ailments of patients with neuropathic pain. The mechanisms of the cognitive modulation of pain and hyperalgesia are not yet understood in this group of patients. The investigators plan to use NGF injection as a model of non-inflammatory neuropathic pain in healthy subjects to investigate the underlying neuronal mechanisms of this hyperalgesia using functional magnetic resonance imaging and resting state network analysis.
single injection of NGF into the volar forearm / single injection of NaCl into the volar forearm
Inclusion Criteria: no acute or chronic disease no acute or chronic pain age: 18-60 years male no medication use Exclusion Criteria: metallic parts in the body claustrophobia drug or substance abuse