Comparison of Blood Loss Following Total Hip Arthroplasty With the Use of Three Thromboprophylactic Regimes: Dabigatran, Enoxaparin and Rivaroxaban.
Lead SponsorCentre of Postgraduate Medical Education
Indication/ConditionHip Osteoarthritis Blood Loss
Intervention/Treatmentdabigatran enoxaparin rivaroxaban ...
The purpose of this study is to determine which of the following drugs: enoxaparin, dabigatran and rivaroxaban causes least blood loss after total hip replacement (THR).
enoxaparin 40mg 1x1 s.c. daily, once preoperatively and then daily for 28 days
rivaroxaban 10 mg 1x1 p.o. daily for 28 days after the surgery
dabigatran 110 mg 1x1 p.o. postoperatively and then 1x2 p.o. for 27 days after the surgery
Inclusion Criteria: primary, end-stage hip osteoarthritis requiring total hip arthroplasty Exclusion Criteria: inflammatory arthropathies liver disorders neoplastic conditions clotting disorders