Official Title

Ketamine and Morphine Versus Morphine Alone for the Treatment of Acute Pain in the Emergency Department
  • Phase

  • Study Type

  • Status

    Unknown status
  • Study Participants

Our goal is to study whether giving people low dose ketamine along with morphine when they come to the Emergency Department will help their pain more than giving morphine by itself. There have been many studies showing that low dose ketamine is safe and effective for pain control. Ketamine is frequently used for pain control in ambulances and helicopters transporting injured patients to the hospital and has also been used for pain control in people who have just had surgery. The investigators would like to see if low dose ketamine would be safe and effective for patients with pain in the Emergency Department.

Patients are eligible for the study if they come to the Emergency Department and their treating physician decides to treat them with morphine (with certain exceptions such as pregnant patients and patients with eye injuries). They will be given information about participating in the study and if they agree, they will be given the study drug. The study drug will be either ketamine or salt water (saline). If patients continue to be in pain they will continue to receive doses of morphine just as they would if they were not in the study. If the treating physician feels that morphine alone is not enough, they will be free to choose another pain medication as they would normally.
Study Started
Jun 30
Primary Completion
Mar 31
Study Completion
Mar 31
Last Update
Jul 17

Drug Ketamine

0.3mg/kg ketamine

Drug Morphine

Dosage of morphine determined by treating physician

Drug placebo

saline of same volume as appropriate weight based dose of ketamine

Morphine and placebo Active Comparator

Patient's will receive morphine during the usual course of their emergency department care and will receive a saline in a volume equivalent to the ketamine administered in the experimental arm of the stuy

Morphine and Ketamine Experimental

Patient's will receive a 0.3mg/kg dose of ketamine in addition to morphine given in the usual course of emergency department care


Inclusion Criteria:

Presenting to Emergency Department in acute pain
age 18 and over
determined to require morphine for pain control by treating physician

Exclusion Criteria:

Patients presenting with headache or head injury
Patient with eye injury or eye pain
Nontraumatic chest Pain
Pregnant patients or women of childbearing potential
Patients allergic to morphine or ketamine
Patients with known history of narcotic/alcohol abuse or presenting for narcotic medication refill
Patients with hypertension: diastolic blood pressure > 100 OR systolic blood pressure > 180
Patient whose pain is so severe that they are unable to give informed consent
Patients who have had bad experiences to prior hallucinations from any origin
No Results Posted