Tolerance of Two Forms of Vitamin C in Acid-sensitive Adults
A Randomized, Double-blind, Crossover Study Comparing the Tolerance of Two Forms of Vitamin C in Acid Sensitive Adults
  • Phase

  • Study Type

  • Status

    Completed No Results Posted
  • Indication/Condition

  • Intervention/Treatment

    vitamin c ...
  • Study Participants

The purpose of this study is to compare the tolerance of two forms of vitamin C in adults with sensitivity to acidic foods.
Study Started
Mar 31
Primary Completion
Jun 30
Last Update
Jun 10

Dietary Supplement Calcium ascorbate

Dietary Supplement Ascorbic acid

Calcium ascorbate -> ascorbic acid Experimental

Ascorbic acid -> calcium ascorbate Experimental


Inclusion Criteria:

Healthy as determined by laboratory results and medical history
Females not of child bearing potential
Self-reported sensitivity to acidic foods
Agrees to consume a low vitamin C diet

Exclusion Criteria:

Pregnant, breastfeeding, or planning to become pregnant during the trial
Use of medications known to interact with vitamin C or cause epigastric effects
Use of supplements containing containing vitamin C
Duodenal ulcer or gastric ulcer, gastritis, hiatus hernia, or gastroesophageal reflux disease (GERD) within past 3 months
Use of antacids and/or acid suppressors within 4 weeks of randomization
History of irritable bowel syndrome and related disorders
Alcohol use > 2 standard alcoholic drinks per day; alcohol or drug abuse within the past year
History of cardiac disease within the past 6 months
History of or current diagnosis of cancer
Uncontrolled hypertension
Unstable renal and/or liver disease
History of kidney stones
Unstable psychiatric disorder
History of or current immunocompromise
History of hemoglobinopathies
Participation in another clinical research trial <30 days
Abnormal liver function
Serum creatinine > 1.5 x upper limit of normal (ULN)
Anemia of any etiology
Uncontrolled and/or untreated thyroid disorder
BMI ≥ 35 kg/m2
Unstable medications <30 days
Allergy or sensitivity to test article ingredients
Cognitively impaired and/or unable to give informed consent
No Results Posted