Effects of Berries and Berry Fractions on Metabolic Diseases
The Effect of the Bioactives of Sea Buckthorn and Bilberry on the Risk of Metabolic Diseases
  • Phase

  • Study Type

  • Status

    Completed No Results Posted
  • Intervention/Treatment

    prulifloxacin bilberry ...
  • Study Participants

The study hypothesis is that the bioactive compounds of sea buckthorn berries (Hippophaë rhamnoides), their fractions, and bilberries (Vaccinium myrtillus). have positive effects on lipid and carbohydrate metabolism and will thus reduce the risk of developing metabolic diseases.
The aim of the project was to investigate whether it is possible to reduce the risk of metabolic diseases with supplementing the diet with sea buckthorn berries (Hippophaë rhamnoides), their bioactive fractions, and bilberries (Vaccinium myrtillus). The study design was a randomized cross-over clinical trial. The participants were slightly and moderately overweight female subjects. In total, 110 female volunteers were recruited, and they followed four different berry diets (bilberry, sea buckthorn, sea buckthorn phenolic extract and sea buckthorn oil) in a randomized order for 33-35 days. Each intervention was followed by a wash-out period of 30-39 days. Blood samples were drawn and physical measurements were performed after each period. Eighty volunteers completed the study. Different markers of lipid and carbohydrate metabolism and inflammation were measured form the blood samples.
Study Started
Jun 30
Primary Completion
Jun 30
Study Completion
Aug 31
Last Update
May 22

Dietary Supplement Bilberries

Frozen bilberries, 100 g/d

Dietary Supplement Sea buckthorn berry

Dried sea buckthorn berries, 20 g/d

Dietary Supplement Sea buckthorn phenolic extract

Ethanol-water extract from sea buckthorn berries, combined with maltodextrin, 14.6 g/d (7.3 g sea buckthorn extract + 7.3 g maltodextrin)

Dietary Supplement Sea buckthorn oil

Sea buckthorn oil, 4 g (8 capsules)/d

bilberry Experimental

sea buckthorn berry Experimental

sea buckthorn phenolic extract Experimental

sea buckthorn oil Experimental


Inclusion Criteria:

BMI 26-34
total cholesterol 4.5-8 mmol/l
LDL chol >2.5 mmol/l
triglycerides <4 mmol/l
glucose <6 mmol/l
insulin <25 mU/l
blood pressure <160/99 mm Hg
hemoglobin >120 g/l
thyroid-stimulating hormone 0.3-4.2 mU/l
ALAT <60 U/l
creatinine <115 umol/l

Exclusion Criteria:

regular smoking
previously diagnosed diabetes (other than gestational)
thyroid, renal, hematological, or hepatic dysfunction
previous myocardial infarction
cardiovascular medication
treatment with regular medication other than allergy medication or joint lubricates
on-going inflammatory disease
No Results Posted