Vitamin D Supplementation in Glomerular Disease
Pilot Study: Efficacy and Safety of Vitamin D Supplementation in Glomerular Disease
  • Phase

  • Study Type

  • Status

    Completed No Results Posted
  • Intervention/Treatment

    vitamin d3 ...
  • Study Participants

This multi-site, pilot study will assess vitamin D supplementation in children and young adults with Glomerular Disease. .
Vitamin D deficiency has been linked to a variety of adverse health outcomes. Nephrotic patients have very low vitamin D levels, and the underlying mechanisms are not known. Furthermore, approaches to safely and effectively supplement vitamin D in these patients have not been established. The purpose of this research study is to learn if vitamin D supplementation is safe and effective in patients with primary glomerular disease and to also help establish the treatment guidelines. About 35 patients with primary glomerular disease, ages 5-30 years old, will take part in this study. Participants will be asked to take vitamin D supplements each day for 12 weeks and will have 3 study visits.
Study Started
Apr 30
Primary Completion
Sep 30
Study Completion
Sep 30
Last Update
Aug 12

Dietary Supplement Cholecalciferol, 2000 or 4000 IUs by mouth daily for 12 weeks

Supplements will be provided as oral capsules.

  • Other names: Vitamin D

Vitamin D Supplementation Experimental

Cholecalciferol, 2000 or 4000 IUs by mouth daily for 12 weeks


Inclusion Criteria:

Males or females, age 5-30 years
Diagnosis of primary glomerular disease (such as steroid-resistant nephrotic syndrome, minimal change disease, FSGS, membranous nephropathy, membranoprolfierative glomerulonephritis, and Immunoglobulin A [IgA] nephropathy) without systemic inflammatory disorders (i.e. lupus, vasculitis)
Serum 25(OH)D level <30 ng/ml and urine protein:creatinine ratio ≥0.5 at Screening Visit.

Exclusion Criteria:

estimated Glomerular Filtration Rate (eGFR) <30 ml/min/1.73m2 at Screening Visit
Serum phosphorus > 5.5 mg/dl or hypercalcemia
Chronic medical conditions or medications unrelated to the renal disease that may impact vitamin D status
Known history of kidney stone(s)
No Results Posted