Selenium in the Prevention of Cancer
Prevention of Cancer by Intervention With Selenium - A Pilot Study in a Danish Population
This is a pilot study proceeding an intended international trial.
Hypothesis: Daily intake of selenium supplementation in the form of selenium-enriched yeast tablets will reduce the risk of cancer in healthy individuals.
Objective: The objective of this pilot study was to assess the viability of a full scale randomised trial.
AMENDMENT TO STUDY OBJECTIVE: Mortality analysis during intervention and follow-up as specified in the sections concerning study design and outcome measures.
Inclusion Criteria: WHO performance status 0 or 1 No active liver- or kidney disease (Serum ALAT (alanine aminotransferase), alkalic phosphatase, bilirubin, creatinin or urea within 2 S.D of laboratory reference range) No previous cancer diagnosis No known HIV-infection Participant must understand oral and written information Participant must not use selenium supplementation of above 50 mcg/d Participant must give written consent prior to inclusion