Lornoxicam vs. Paracetamol After Lower Abdominal Surgery
Intravenous Lornoxicam is More Effective Than Paracetamol as a Supplemental Analgesic After Lower Abdominal Surgery; A Randomized Controlled Trial
Lead SponsorImam Abdulrahman Bin Faisal University
StatusCompleted No Results Posted
Intervention/Treatmentlornoxicam acetaminophen ...
Background: The aim of this prospective, randomized, double-blind study is to determine the most effective supplemental analgesic, paracetamol or lornoxicam for postoperative pain relief after lower abdominal surgery.
Methods: Sixty patients scheduled for lower abdominal surgery under general anesthesia were randomly allocated to receive either isotonic saline (Control group), intravenous paracetamol 1 g every 6 h (Paracetamol group) or lornoxicam 16 mg then 8 mg after 12 h (Lornoxicam group). Additionally pain was treated postoperatively using morphine patient-controlled analgesia. Postoperative pain scores measured by the verbal pain score (VPS), morphine consumption and the incidence of side effects were measured at 1, 2, 4, 8, 12 and 24 hours postoperatively.
IV paracetamol infusion
16 mg at skin closure and 8 mg 12 hours postoperative
Lornoxicam 16 mg will be given at skin closure and 8 mg will be given 12 hours postoperatively
Patients will receive normal saline at skin closure, at 6, 12, 18 hours postoperatively.
1 gm of paracetamol will be given at skin closure, 6, 12, 18 hours postoperatively
Inclusion Criteria: lower abdominal surgery Exclusion Criteria: body weight more than 150% of their ideal body weight history of significant cardiac, pulmonary, renal, hepatic or hematological disease; chronic drug or alcohol abuse; hypersensitivity to any of the studied drugs; bronchial asthma; gastritis or peptic ulcer; and pregnancy patients who received any analgesic drug a day before surgery