Title

Platelet Function Analysis in Head Trauma: ASA/Plavix
Platelet Function Analysis in Head Trauma: ASA/CLOPIDOGREL
  • Phase

    N/A
  • Study Type

    Interventional
  • Status

    Completed No Results Posted
  • Study Participants

    97
The investigators are assessing the platelet function analysis of those who sustained significant head trauma while on aspirin or plavix and to assess if any qualitative difference is obtained if platelets are administered.
The platelet function analyzer VerifyNow® P2Y12 uses ADP as agonists to induce platelet activation and ascertain the level of platelet function impaired by these medications. VerifyNow® Aspirin Assay utilizes arachidonic acid as the agonist to measure platelet function specifically along this pathway. Our research question for this study is as follows:

Does the administration of desmopressin (DDAVP) and/or the transfusion of platelets in patients with head trauma reverse the platelet inhibition caused by Aspirin and/or Plavix? The investigators hypothesize that with the administration of platelets and/or DDAVP that there is a reversal of the inhibition.
Study Started
Oct 31
2009
Primary Completion
Nov 30
2011
Study Completion
Nov 30
2011
Last Update
Feb 16
2012
Estimate

Biological Platelets

1 unit of platelets

Drug DDAVP

Desmopressin 0.3mcg/kg IV x 1

Platelets/DDAVP Active Comparator

Fall on ASA/Plavix that sustained head trauma requiring administration of platelets and/or DDAVP

No Platelets No Intervention

Those that sustain head trauma NOT requiring platelet transfusion. The investigators are evaluating platelet function in those not requiring platelet transfusion

Criteria

Inclusion Criteria:

Age > 18yrs
Must be a trauma patient with blunt head trauma.
Must be on Aspirin and/or Plavix
Subject or Legally Authorized Representative (LAR) (per Heath and Safety Code, Sections 24170 to 24179.5) must sign study consent within 4 hours from the first blood draw. (If this criterion is not met the initial blood draw must be destroyed and NOT run for study results).

Exclusion Criteria:

Hemoglobin ≤ 10 GM/DL
Platelet Count ≤ 150 K/MCL
Pregnant Females
Subjects on Warfarin, Heparin or Enoxaparin
No Results Posted