Trial | NCT01501786  Report issue

Title

Does Ketamine Attenuate Depression of Respiratory and Cardiac Functions
The Effect of Small-dose Ketamine on Depression of Respiratory and Cardiac Functions Caused by Propofol in Pediatric Cardiac Catheterization

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    ketamine ...

  • Study Participants

    150
Normal cardiac and respiratory functions should be maintained during pediatric cardiac catheterization. Propofol has become a popular choice for sedation in children, however, it depresses cardiac and respiratory functions. Some investigators reported that ketamine attenuates its depressant effect, but it remains unclear whether ketamine reduces cardiac and respiratory depression caused by propofol in pediatric cardiac catheterization.
Study Started
Jan 31
2012
Primary Completion
May 31
2013
Study Completion
May 31
2013
Last Update
Jul 30
2013
Estimate

Drug control

propofol 8mg/kg/h saline 0.24 ml/kg/h

  • Other names: saline with propofol

Drug Ket10

propofol 6.4 mg/kg/h ketamine 10 microg/kg/min

  • Other names: ketamine 10 γ

Drug Ket20

propofol 4.8 mg/kg/h ketamine 20 microg/kg/min

  • Other names: ketamine 20 γ

Ket10 Experimental

ketamine is co-administered with propofol

Ket20 Experimental

ketamine is co-administered with porpofol

control Sham Comparator

propofol and saline are administered

Criteria 

Inclusion Criteria:

7kg-25kg (6mo-10yrs) children who undergo cardiac catheterization

Exclusion Criteria:

patients who have neurological disease,
endocrinological disease,
airway anomaly, who require positive pressure ventilation
No Results Posted