A Clinical Trial to Study the Efficacy and Safety of Different Doses of Bone Marrow Derived Mesenchymal Stem Cells in Patients With Critical Limb Ischemia Due to Buergers Disease
A Non-randomized, Open Label, Multicentric, Dose Ranging , Phase II Study Assessing the Efficacy and Safety of Intramuscular Administration of Stempeucel - CLI™ (ex Vivo Cultured Adult Bone Marrow Derived Allogeneic Mesenchymal Stem Cells) in Patients With Critical Limb Ischemia Due to Buerger's Disease
  • Phase

    Phase 2
  • Study Type

  • Status

    Completed No Results Posted
  • Study Participants

This is an open label, non-randomized, dose ranging study to evaluate the safety and efficacy of different doses of Stempeucel in critical limb ischemia patients.
Study Started
Jan 31
Primary Completion
Feb 28
Study Completion
Mar 31
Last Update
Sep 13

Biological Allogeneic Mesenchymal Stem Cells

Single intramuscular administration of low dose of stem cells

  • Other names: Stempeucel - CLI

Biological Allogeneic Mesenchymal Stem Cells

Single intramuscular administration of intermediate dose of stem cells

  • Other names: Stempeucel - CLI

Low dose Experimental

Stempeucel - CLI will be administered at the lowest dose

Intermediate dose Experimental

Stempeucel - CLI will be administered at intermediate dose

Control arm No Intervention

Standard protocol of care alone


Inclusion Criteria:

Buerger's disease as diagnosed by Shionoya criteria
Males or females (willing to use accepted methods of contraception during the course of the study) in the age group of 18-65 yrs
Established CLI in the study limb, clinically and hemodynamically confirmed as per Rutherford- III-5
Patients in Rutherford- III-6 if gangrene extending maximally up to the head of metatarsal but limited to toes (Patients with wet gangrene must undergo wound debridement / amputation before screening)
Patients having infrapopliteal occlusive disease with rest pain and ischemic ulcer/necrosis, who are not eligible for or have failed traditional revascularization treatment as per the investigators judgment (No option patients)
Ankle Brachial Pressure Index (ABPI) ≤ 0.6 or ankle pressure ≤ 50 mm Hg or TcPO2 ≤ 40 mmHg in the foot of the study limb
Patients who are able to understand the requirements of the study, and willing to provide voluntary written informed consent and video consent, abide by the study requirements, and agree to return for required follow-up visits

Exclusion Criteria:

Patients with CLI indicated for major amputation during screening
Atherosclerotic PAD
Ulcers with exposure of tendon and/bone in the shin region
Previous above transmetatarsal amputation in study limb
Any Lumbar sympathectomy procedure performed less than 90 days prior to the screening
Patients with gait disturbance for reasons other than CLI
Diagnosis of diabetes mellitus (type 1 or type 2)
Patients having left ventricular ejection fraction < 35%
Patients suffering from clinically relevant peripheral neuropathy
History of Stroke or myocardial infarction
Patients who are contraindicated for MRA
Patients with deep vein thrombosis in any limb
Patients who have clinically serious and/or unstable inter-current infection, medical illnesses or conditions that are uncontrolled or whose control, in the opinion of the Investigator, may be jeopardized by participation in this study or by the complications of this therapy
Documented terminal illness or cancer or any concomitant disease process with a life expectancy of <1 year
Patients already enrolled in another investigational drug trial or completed within 3 months or those who have participated in any stem cell clinical trial
Patient with known hypersensitivity to the constituents of the IMP - dimethyl sulfoxide (DMSO) or human serum albumin (HSA)
History of severe alcohol or drug abuse within 3 months of screening
Hb% < 10 gm% for males, Hb% < 9 gm% for females, serum creatinine ≥ 2mg%, serum Total Bilirubin ≥2mg%
Pregnant and lactating women
Patients tested positive for HIV 1, HCV, HBV, CMV, RPR
No Results Posted