Intermittent Parasite Clearance (IPC) in Schools: Impact on Malaria, Anaemia and Cognition
Intermittent Parasite Clearance (IPC) in Schools: a Randomised Double-blind Placebo-controlled Trial of the Impact of IPC on Malaria, Anaemia and Cognition Amongst School Children in Kedougou, Senegal
  • Phase

  • Study Type

  • Status

    Completed No Results Posted
  • Study Participants

Although the risk of malaria is greatest in early childhood, significant numbers of schoolchildren remain at risk from malaria infection, clinical illness and death. By the time they reach school, many children have already acquired some clinical immunity and the ability to limit parasite growth, and thus most infections are asymptomatic and will go undetected and untreated. Asymptomatic parasitaemia contributes to anaemia, reducing concentration and learning in the classroom, and interventions aiming to reduce asymptomatic parasite carriage may bring education, as well as health, benefits.

Intermittent parasite clearance (IPC) delivered through schools is a simple intervention, which can be readily integrated into broader school health programmes, and may usefully supplement the community-distribution of insecticide-treated nets (ITNs) in countries with a policy of universal coverage of nets.

This study seeks to establish whether intermittent parasite clearance undertaken once a year at the end of the malaria transmission season can reduce malaria parasite carriage and anaemia amongst school-going children already using insecticide-treated nets, and its consequent impact on school attendance and performance, in order to assess its suitability for inclusion as a standard intervention in school health programmes in areas of seasonal malaria transmission.
Study Started
Nov 30
Primary Completion
Feb 29
Study Completion
Feb 29
Last Update
Apr 19

Drug Intermittent parasite clearance

Sulphadoxine-pyrimethamine (500/25mg) according to age, given on day 1; Amodiaquine (200mg) according to age, given daily for 3 days

Other Placebo

Placebo tablets, similar in appearance and taste to active treatment, given daily over 3 days

Intermittent parasite clearance Active Comparator

Children sleeping under a long-lasting insecticidal net (LLIN) receive an additional intermittent preventive treatment for clearance of asymptomatic malaria infection given once a year at the end of the malaria transmission season

Control Placebo Comparator

Children sleeping under a long-lasting insecticidal net (LLIN) receive placebo


Inclusion Criteria:

enrolled in participating elementary schooled
provision of parental consent

Exclusion Criteria:

lack of consent
chronic conditions which limit regular school attendance
clinical malaria on the day of scheduled treatment (as defined as febrile, with a positive result in a rapid diagnostic test for malaria).
No Results Posted