TLR-9 Antagonism in Steroid Resistant Optic Neuritis
Outcomes of TLR-9 Antagonism in Steroid Resistant Optic Neuritis; A Pilot Study
Although idiopathic steroid resistant optic neuritis is very uncommon, there is no established treatment protocol for such patients. Toll like receptors (TLRs) especially TLR-9 has been shown to play a role in the pathogenesis of optic neuritis. This small case series aims to determine whether immunomodulators directed specifically at TLR-9(i.e. TLR-9 antagonism)play any role in improving the visual function in such patients.
0.5 ml of Mw in 500ml 0.9% normal saline administered over two hours as an infusion. 2ml(4mg/ml) of dexamethasone administered two hours prior to Mw administration
Inclusion Criteria: Unilateral Steroid Resistant Optic Neuritis Exclusion Criteria: bilateral optic neuritis Associated Systemic disease Prior treatment received