Long-term Iron Supplements and Malaria Risk in Early Pregnancy: a Randomized Controlled Trial
Malaria Risk Prior to and During Early Pregnancy in Nulliparous Women Receiving Long-term Weekly Iron and Folic Acid Supplementation (WIFS): a Non-inferiority Randomized Controlled Trial
  • Phase

  • Study Type

  • Status

    Completed No Results Posted
  • Intervention/Treatment

    iron folic acid ...
  • Study Participants

A randomized double-blind controlled trial will be carried out in which young, nulliparous (having never given birth) women will be randomly assigned to receive weekly supplementation with either iron and folic acid or folic acid alone. Women will be followed-up weekly up to 18 months. Women who become pregnant will be followed-up until delivery. Malaria risk in both groups will be compared by assessing the prevalence of peripheral parasitaemia at the first antenatal clinic visit for pregnant women and at the end of the first malaria transmission season for non-pregnant women. The incidence of clinical malaria will be assessed by active and passive case detection throughout the follow-up period.
Study Started
Apr 30
Primary Completion
Nov 30
Study Completion
Jan 31
Last Update
Mar 19

Dietary Supplement Folic Acid


Dietary Supplement Folic Acid and Iron

60mg Iron and 2.8mg Folic Acid

Folic Acid Active Comparator

2.8mg of Folic Acid given weekly

Folic Acid and Iron Experimental

2.8mg Folic Acid and 60mg Iron given weekly


Inclusion Criteria:

At least 15 and less than 25 years old at enrolment
Never given birth
Resident within the Demographic Surveillance System (DSS) area
Willing to adhere to the study requirements (including weekly observed drug intake)
Provision of written informed consent (if non emancipated minor by guardian/parent with minor's assent

Exclusion Criteria:

No menses for >3 months and/or palpable uterus or positive pregnancy test if history unclear
Concurrent enrolment in another study
Intention to move out of the study area for more than 2 months within the next 18 months
Any significant illness at the time of screening that requires hospitalization, including clinical signs of severe anaemia (conjunctival or mucosal pallor, tachycardia, respiratory distress)
History or presence of major clinical disease likely to influence pregnancy outcome (sickle cell disease, diabetes mellitus, severe renal or heart disease, open tuberculosis, epilepsy)
No Results Posted