Diastolic Heart Failure Management by Nifedipine
Lead SponsorDemand Investigators
Indication/ConditionDiastolic Heart Failure
Patients with heart failure with preserved ejection fraction have a equally high risk for mortality and re-hospitalization as those with reduced ejection fraction. Effective management strategies are critically needed to be established for this type of heart failure. These patients have more hypertensive and ischemic etiology than those with reduced ejection fraction. The investigators hypothesis is that Ca channel blocker nifedipine can improve the heart failure clinical composite response endpoint compared with the conventional treatment in patients with heart failure with hypertension and/or coronary artery disease and preserved ejection fraction (>=50%) by echocardiography. This study is multi-center, prospective, randomized, open-label, and blinded-endpoint design.
Participants will receive 10 to 60 mg of sustained-release nifedipine once a day until December 2014
Inclusion Criteria: 20 years and older Heart failure with history of hypertension and/or coronary artery disease LVEF > or = 50% on echocardiography Exclusion Criteria: Valvular heart diseases with significant regurgitation and/or stenosis Hypertrophic cardiomyopathy, restrictive cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and active myocarditis Constrictive pericarditis Cardiogenic shock Planned coronary artery bypass grafting or percutaneous coronary intervention within 3 months History of acute coronary syndrome or stroke within 3 months Pregnancy or breastfeeding Hypersensitivity or contraindication to nifedipine Inability to obtain informed consent Any conditions not suitable for the participation in this trial judged by the investigator