Official Title

Probiotics for Reduction Of Markers In Subjects With Allergy
  • Phase

    N/A
  • Study Type

    Interventional
  • Status

    Completed No Results Posted
  • Intervention/Treatment

    lactobacillus plantarum lactobacillus casei ...
  • Study Participants

    60
In vitro studies reveal immunomodulatory effects of probiotic bacteria that are strain-dependent. Differential immunomodulatory in vitro capacities can not be extrapolated directly to in vivo efficacy. Thus, in vitro screening should be followed by comparative analysis of the selected immunomodulatory probiotic strains in an in vivo setting. Birch pollen allergy is one of the most common forms of respiratory allergy in European countries, and recognized by a Th2-skewed immune system. Five Lactobacillus strains will be evaluated for their immunomodulatory properties in birch pollen sensitive subjects outside the hay fever season. A double-blind placebo-controlled parallel study will be performed in which subjects with a proven birch pollen allergy will consume one of 5 different probiotic yoghurts containing 4 L. plantarum strains and 1 L. casei strain or a placebo yoghurt. Blood samples are collected at the start and after 4 weeks. Immune parameters are determined in serum and peripheral blood mononuclear cell cultures (hPBMC) derived from these subjects.
Study Started
Nov 30
2008
Primary Completion
Dec 31
2008
Study Completion
Dec 31
2008
Last Update
Jun 04
2010
Estimate

Dietary Supplement Yoghurt with L. plantarum strain

Intake of yoghurt during 4 weeks

Dietary Supplement Yoghurt with L.casei

Intake of yoghurt during 4 weeks

Dietary Supplement Yoghurt with L. plantarum strain

Intake of yoghurt during 4 weeks

Dietary Supplement Yoghurt with L. plantarum strain

Yoghurt with L. plantarum strain

Dietary Supplement Yoghurt with L. plantarum strain

Intake of yoghurt during 4 weeks

Dietary Supplement Yoghurt

Intake of yoghurt during 4 weeks

Yoghurt with Lactobacillus strain (L.plantarum WCFS1) Experimental

Yoghurt with Lactobacillus strain (L.plantarum NIZO3400) Experimental

Yoghurt with Lactobacillus strain (L. plantarum NIZO2877) Experimental

Yoghurt with Lactobacillus strain (L.plantarum CBS125632) Experimental

Yoghurt with Lactobacillus casei Shirota Active Comparator

Placebo Yoghurt Placebo Comparator

Criteria

Inclusion Criteria:

birch pollen sensitive subjects
Positive RAST or intracutane skintest
age 18-50
signed informed consent form

Exclusion Criteria:

use of probiotics
known allergy for pets (home setting)
use of medication influencing the immune system
use of antibiotics
lactose intolerance
pregnancy
infection
No Results Posted