Official Title

Treatment of Chronic Fatigue Syndrome and Fibromyalgia With D-ribose- a Multicenter Study
  • Phase

  • Study Type

  • Status

    Completed No Results Posted
  • Intervention/Treatment

    d-ribose ...
  • Study Participants

To determine whether adding Ribose 5 grams 3 x day would improve quality of life, energy, sleep and cognitive function and decrease pain in patients with CFS and/or fibromyalgia (CFS/FMS).
Chronic Fatigue Syndrome and Fibromyalgia (CFS/FMS) are debilitating syndromes affecting ~ 2-4% of the population. Although they are heterogeneous conditions associated with many triggers, including infections, autoimmune illnesses, hormonal dysfunctions and other processes, they appear to have the common pathology of being associated with impaired energy metabolism.

As D-ribose has been shown to increase cellular energy synthesis in heart and skeletal muscle, and was shown to significantly improve clinical outcomes in CFS/FMS in an earlier pilot study, we conducted a larger, community based, multicenter trial to see if these findings could be generalized to a broader patient population. We hypothesized that giving D-ribose would improve function in CFS/FMS patients.
Study Started
Apr 30
Primary Completion
Sep 30
Study Completion
Sep 30
Last Update
Apr 22

Dietary Supplement Ribose

Ribose 5 grams PO TID was taken daily

  • Other names: D-ribose, corvalen


Inclusion Criteria:

diagnosed with Fibromyalgia (FMS) (by American College of Rheumatology [ACR] criteria) and/or Chronic Fatigue Syndrome (CFS- by Centers for Disease Control [CDC] criteria) by a health practitioner.

Exclusion Criteria:

pregnant or nursing women, or
any participants with known severe medication or nutrient sensitivities, or
previous ribose use.
No Results Posted