Study of Mitomycin C and Nasal Splint to Treat Nasal Synechiae
Comparative Study of Mitomycin C and Internal Nasal Septal Splint in the Treatment of Nasal Synechiae
Lead SponsorKarnataka Institute of Medical Sciences
StatusCompleted No Results Posted
Indication/ConditionNasal Synechiae Adhesions of Nasal Cavity Nasal Adhesions ...
This study evaluates whether Mitomycin C is an effective alternative to septal splints in the treatment of nasal synechiae.
Nasal synechiae is an important cause for the failure of many a nasal surgery. Septal splints have been widely used for the treatment of nasal synechiae, but are associated significant morbidity until removal. To the best of our knowledge there are no studies in literature comparing Mitomycin C with septal splints as an atraumatic alternative in the treatment of nasal synechiae. This is a preliminary study taken up to evaluate the therapeutic efficacy of Mitomycin C in the treatment of nasal synechiae.
Cotton wick soaked with 1mg/ml of mitomycin c placed for 2 minutes between the raw surfaces after synechiolysis with surgical blade no.15
Teflon internal nasal septal splint placed between the raw surfaces and secured at the anterior end of septum with catgut 3-0 sutures, following synechiolysis with surgical blade no.15. Splint removed at the end of one week
Cases recruited into this arm receive topical application of mitomycin c (1mg/ml)following surgical synechiolysis
Cases recruited into this arm receive insertion of teflon internal nasal septal splint following surgical synechiolysis
Inclusion Criteria: Patients with nasal mucosal synechiae due to surgical or non-surgical trauma Exclusion Criteria: Patients with nasal vestibular stenosis Patients with nasal synechiae due to diseases like Hansen's disease, Syphilis, Rhinoscleroma, Atrophic Rhinitis etc.