Vitamin D3 Supplementation and the T Cell Compartment in Multiple Sclerosis (MS)
The Effects of Vitamin D3 Supplementation on the T Cell Compartment in Multiple Sclerosis; a Pilot Study
  • Phase

  • Study Type

  • Status

    Completed No Results Posted
  • Intervention/Treatment

    vitamin d3 ...
  • Study Participants

In patients with Relapsing Remitting Multiple Sclerosis (RRMS), the investigators observed a positive correlation between regulatory T cell (Treg) function and vitamin D status. The present goal is to assess whether Treg function improves on supplementation with vitamin D3.
In several studies, Multiple Sclerosis (MS) incidence and disease activity has been related with vitamin D status. We observed that RRMS patients who remained relapse free before blood collection had a better vitamin D status than patients who experienced relapses (Smolders et al. Mult Scler 2008;17:1220-1224). Since vitamin D3 is a potent promotor of T cell regulation in vitro (Smolders et al. J Neuroimmunol 2008;194:7-17), we hypothesised that a promotion of Treg function in MS patients might underlie its association with MS disease activity. In a cohort of RRMS patients, we observed a positive correlation of Treg function with vitamin D status (Smolders et al. PLoS ONE 2009;4:e6635). Furthermore, vitamin D status correlated positively with a Th1/Th2-balance which was more directed towards Th2. In the present study, we will assess whether treatment of RRMS patients with vitamin D3 promotes T cell regulation.

In the present study, RRMS patients will be supplemented with vitamin D3, and regulatory T cell tests will be performed before and after supplementation.
Study Started
Aug 31
Primary Completion
Mar 31
Study Completion
Jul 31
Last Update
Aug 11

Dietary Supplement vitamin D3

Oil-based solution, 1 dose of 500 microgram each day, during 3 months.

  • Other names: Vigantol Oil (Merck)

Vitamin D3 Experimental

Patients receive 1dd 500ug vitamin D3 for 3 months


Inclusion Criteria:

Relapsing Remitting MS (Revised MCDonald criteria 2005)
Age > 18 years

Exclusion Criteria:

Progressive MS phenotype
Abnormalities of vitamin D hormonal system other than low dietary intake or limited sun exposure
Intake of drugs that influence vitamin D homeostasis other than corticosteroids
Conditions with in increased susceptibility to hypercalcemia
Alcohol or drug abuse
Pregnancy or the intention to become pregnant within the study period
No Results Posted