Effect of Immunocal® With Exercise Versus Casein With Exercise on Aging Processes in Elderly Persons
Effect of the Cysteine-rich Whey Protein Isolate (Immunocal®) in Combination With Physical Exercise on Muscle Function, Body Composition and Inflammatory Cytokine Levels in Elderly Persons: A Randomized, Double-blind Study
  • Phase

    Phase 2
  • Study Type

  • Status

    Completed No Results Posted
  • Intervention/Treatment

    cow milk ...
  • Study Participants

Aging is typically associated with a decrease in skeletal muscle mass and muscle function, which contributes decisively to disability in old age and to the loss of quality of life.Resistance exercise can increase muscle strength, function and mass in older adults.

The primary aim of this study is to determine whether the combination of resistance training with a supplementation of a cysteine- rich whey protein isolate (Immunocal) compared to combination of resistance training with casein used as control (casein contains little cysteine) could have the potential to provide a synergic beneficial impact on muscle mass and function which could translate to an improved quality of life in elderly persons.
Study Started
Jun 30
Primary Completion
Jul 31
Study Completion
Mar 31
Last Update
Feb 09

Dietary Supplement Immunocal

20 grams per day of Immunocal for 135 days.

Dietary Supplement Casein

20 grams per day for 135 days

Immunocal Active Comparator

20g of Immunocal

Casein Placebo Comparator

20g of Casein


Inclusion Criteria:

Age 65 or older
Estimated GFR above 45ml/min
Total bilirubin in the normal range (0.2 to 1.2 mg/dl) AST (10-35 U/L for women and 10-50 U/L for men). ALT equal to or less than 2.5 times the upper limit of normal
BMI between 18.5-29.9 (kg)/m2
Sedentary (< 2 hours of structured exercise)in the last 2 or 3 months
Based on investigator judgment according to current Canadian guidelines, medical conditions such as hypertension, diabetes and hyperlipidemia have to be stable and optimally controlled before the subject starts the study.

Exclusion Criteria:

History of angioedema or allergic reactions to any compound used in this study.
Milk protein intolerance
Subjects currently using N-acetylcysteine, alpha-lipoic acid supplements, or dry whey protein supplements.
Major surgery in the year prior to testing
Acute coronary or vascular event within the last year or progressive angina
Stroke within the past 2 years
Neurologist and/or orthopedic limitations
Uncontrolled thyroid or pituitary disease
Medication which has a major affect on cognitive function
Signs of early dementia as assessed by Mini-Mental State Examination
Weight loss of more than 4kg(or more than 5% body weight) over last 6 months
Alcohol abuse
Medication which interferes with muscle mass i.e. (corticosteroids)
Any life threatening conditions based on Investigator judgment.
Subjects with allergies/intolerance to soya.
Subjects currently undergoing immunosuppressive therapy.
No Results Posted