Title

Single Dose Steroid Before Thyroidectomy for Benign Disease to Improve Postoperative Nausea, Pain, and Vocal Function
Randomized Controlled Trial on Efficacy of Preemptive 8 mg of Dexamethasone for Reducing Pain and Postoperative Nausea and Vomit After Thyroidectomy for Benign Disease.
  • Phase

    Phase 2
  • Study Type

    Interventional
  • Status

    Unknown status
  • Intervention/Treatment

    urea sodium chloride ...
  • Study Participants

    80
The purpose of this study is to evaluate the efficacy of 8 mg of dexamethasone administered prior surgery, to reduce pain, postoperative nausea and vomiting and to improve vocal function after thyroidectomy for benign disease.
Study Started
Jan 31
2009
Primary Completion
Oct 31
2012
Anticipated
Study Completion
Oct 31
2012
Anticipated
Last Update
Sep 05
2012
Estimate

Drug Dexamethasone

20 minutes before total or partial thyroidectomy for benign disease a single dose of intravenous 8 mg/2mL of dexamethasone is administered

Drug saline solution

20 minutes before total or partial thyroidectomy for benign disease 100 mg of saline solutions are administered intravenous

Procedure Thyroidectomy, total or partial

Surgical standard intervention

A (dexamethasone) Active Comparator

20 minutes before total or partial thyroidectomy for benign disease a single dose of intravenous 8 mg/2mL of dexamethasone is administered

B (Control) Placebo Comparator

20 minutes before total or partial thyroidectomy for benign disease 100 mg of saline solutions are administered intravenous

Criteria

Inclusion Criteria:

Age > 18 years
Patients undergoing thyroidectomy

Exclusion Criteria:

Patients who had received antiemetic therapy within 48 hours before surgery
Patients with depression
Chronic pain disorder
Insulin-dependent diabetes mellitus
History of severe and/or repeated PONV after previous minor surgery, that led to change from standard anesthetic protocol
Pregnancy
Age < 18 years
Patients who had known malignant disease or had undergone previous thyroid or neck surgery
No Results Posted