Fermented Milk Drink on Human Intestinal Microflora
Effects of a Fermented Milk Drink Containing Lactobacillus Casei Strain Shirota on the Human Intestinal Microflora
Lead SponsorCheng Hsin Rehabilitation Medical Center
StatusCompleted Results Posted
Indication/ConditionSigns and Symptoms, Digestive
Fermented milk is a popular drink. Recent studies revealed that some fermented milk containing some strains of lactic acid bacteria have health-promoting effects through improvement of the intestinal microflora and modulation of the immune system. Lactobacillus casei strain Shirota (LcS) is a probiotic bacterium used in the production of fermented milk products and lactic acid bacteria preparations. LcS has been shown to modify allergen-induced immune responses in allergic rhinitis, altering fermentation patterns in the small bowel, prevention of recurrent urinary tract infections in women. Yakult®300 is a fermented milk containing at least 3x10^10 live LcS cells per 100 ml bottle. This study aimed to evaluate the effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the human intestinal microflora.
Yakult®300 was given 100 ml once per day for four weeks. Fermented or unfermented milk per 100 ml bottle per day for four week.
Lactobacillus casei strain Shirota
Inclusion Criteria: Healthy adult volunteers and willing to give voluntary written informed consent Exclusion Criteria: Major systemic disease Pregnancy, parturient and feeding woman, or expect to be pregnant Abnormal liver function Abnormal renal function Abnormal gastrointestinal function Take medication for gastrointestinal function Stroke, myocardial infarction, Poor compliance for study protocol
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Fecal specimens were obtained from all 24 healthy volunteers at week 0, 1, 2, 3, 4, 5, 6. Bifidobacterium was cultured. Bacterial colonies were counted.
Fecal specimens were obtained from all 24 healthy volunteers at week 0, 1, 2, 3, 4, 5, 6. Clostridium perfringens was cultured.Bacterial colonies were counted.
Fecal specimens were obtained from all 24 healthy volunteers at week 0, 1, 2, 3, 4, 5, 6. Bacterial colonies were cultured and counted.
Outcome Measure Data Not Reported