Marine Oils and Arthritis
Whale Oil Versus Cod Liver Oil in Rheumatoid Arthritis
  • Phase

  • Study Type

  • Status

  • Study Participants

NSAIDS are associated with adverse GI effects and COX-2 inhibitors have cardiovascular risk. Long-term oral supplementation with fish oil reduce e.g. joint pain in rheumatoid arthritis (R.A) patients, with reduced need for NSAIDS, in addition to being cardioprotective. The aim is to investigate if 4 month supplementation of 15 ml/day of whale blubber oil compared with cod liver oil reduce the intensity of joint pain in patients with R.A (primary outcome). Patients are assessed at inclusion and after study (4 months) during routine polyclinical visit. Patients are called for interview after 6 and 12 weeks. Secondary outcomes are e.g. morning stiffness, quality of life and functional level
Not relevant
Study Started
Dec 31
Primary Completion
Oct 31
Study Completion
Oct 31
Last Update
May 09

Dietary Supplement Cod liver oil

15 ml/day for 4 months, divided on dosage morning and evening, taken orally

Dietary Supplement Whale blubber oil

15 ml/day for 4 months, divided on dosage morning and evening, orally.

1 Experimental

Whale blubber oil

2 Active Comparator

Cod liver oil


Inclusion Criteria:

Rheumatoid arthritis patients according to American College of Rheumatology criteria (with active disease and in remission). Intensity of joint pain last week (30 mm or more on 100 mm Visual analogue scale). Stable use of DMARDS and no corticosteroid injections last 4 weeks before study and during study.

Exclusion Criteria:

Non-Norwegian speaking/reading or not understanding study design or non-compliance. Pregnant/lactating women. Bleeder disease, known HIV or hepatitis, medication with Marevan (blood thinner). Not willing or possible to stop taking regular omega-3 supplements during study.
No Results Posted