Official Title

Acamprosate for Treatment of Compulsive Behaviors and Craving in Parkinson's Disease
  • Phase

  • Study Type

  • Status

  • Study Participants

The purpose of this study is to determine how many patients with Parkinson's disease have compulsive behaviors, and what types of behaviors they have. This study will also determine if acamprosate can be used to treat compulsive behaviors in Parkinson's disease patients.
Study Started
Aug 31
Primary Completion
Sep 30
Study Completion
Sep 30
Last Update
Nov 13

Drug acamprosate

333 mg 2 tabs tid


Inclusion Criteria:

Idiopathic Parkinson's disease
Active dopaminergic therapy at stable dose for one month (levodopa or dopamine agonist)
Able and willing to complete Rating Scales
Presence of one or more compulsive behavior based on responses to Rating Scales (defined as >5 on the SOGS; >17 on the YBOCS-SV and YBOCS-CUV; >1.7 on the SCS for women and >2.1 on the SCS for men; >15 on the YBOCS-BE, >5.5 on the CQ).
Written informed consent

Inclusion criteria (controls):

No significant psychiatric disease
Able and willing to complete Rating Scales
Written informed consent

Exclusion Criteria:

No anticipated need for adjustment of medications for Parkinson's disease
Current participation in another clinical study
History of unstable psychiatric disease (as determined by the Principal Investigator)
Women of childbearing age not using appropriate contraceptive methods (oral contraceptives, condoms, surgery)
No Results Posted