Efficacy of Vitamin C Injection on Fatigue in Workers After Work
Efficacy of High Dose Vitamin C Parenteral Supplement on Amelioration of Fatigue in Company Workers After Work: A Double-Blind, Randomized Controlled Trial
  • Phase

    Phase 2/Phase 3
  • Study Type

  • Status

    Completed No Results Posted
  • Study Participants

Fatigue is one of the most frequently observed symptoms for company workers, and oxidative stress is regarded as one of its cause. Vitamin C is a well-known antioxidant, and the investigators seek for evidence of the efficacy of high dose vitamin C parenteral supplement on fatigue symptoms of company workers after work.
Previous studies dealing with vitamin C were focusing on terminal cancer patients or those with chronic fatigue syndrome. Since used drug dosage and the ways of administering vitamin C were not identical, the results were not consistent throughout those studies. This study is aimed to evaluate the efficacy of high dose vitamin C with parenteral supplement on relieving fatigue for apparently healthy volunteers.
Study Started
Mar 31
Primary Completion
May 31
Study Completion
May 31
Last Update
Apr 10

Dietary Supplement Ascorbic acid (Vitamin C)

Single intravenous injection of vitamin C 10g(20ml) with 100ml of normal saline over 30 minutes

  • Other names: Ascorbic acid, Merit C

Dietary Supplement Normal saline

Single intravenous injection of 120ml of normal saline over 30 minutes

1 Experimental

Intravenous injections of 10 grams(20ml as a solution) of vitamin C with 100ml of normal saline over 30 minutes.

2 Placebo Comparator

Intravenous injections of 120ml of normal saline over 30 minutes.


Inclusion Criteria:

Company workers working at least 5 days a week from morning to evening
Volunteers who provided written informed consent

Exclusion Criteria:

Acute illness
Chronic disease such as diabetes, hypertension, liver disease, or renal disease
Previous history of renal stone or gout
Pregnant or lactating women
Hypersensitivity to vitamins or intravenous injections
History of vitamin supplements orally or parenterally within 2 days
No Results Posted