Efficacy of Vitamin C Injection on Fatigue in Workers After Work
Efficacy of High Dose Vitamin C Parenteral Supplement on Amelioration of Fatigue in Company Workers After Work: A Double-Blind, Randomized Controlled Trial
Fatigue is one of the most frequently observed symptoms for company workers, and oxidative stress is regarded as one of its cause. Vitamin C is a well-known antioxidant, and the investigators seek for evidence of the efficacy of high dose vitamin C parenteral supplement on fatigue symptoms of company workers after work.
Previous studies dealing with vitamin C were focusing on terminal cancer patients or those with chronic fatigue syndrome. Since used drug dosage and the ways of administering vitamin C were not identical, the results were not consistent throughout those studies. This study is aimed to evaluate the efficacy of high dose vitamin C with parenteral supplement on relieving fatigue for apparently healthy volunteers.
Single intravenous injection of vitamin C 10g(20ml) with 100ml of normal saline over 30 minutes
Single intravenous injection of 120ml of normal saline over 30 minutes
Inclusion Criteria: Company workers working at least 5 days a week from morning to evening Volunteers who provided written informed consent Exclusion Criteria: Acute illness Chronic disease such as diabetes, hypertension, liver disease, or renal disease Previous history of renal stone or gout Pregnant or lactating women Hypersensitivity to vitamins or intravenous injections History of vitamin supplements orally or parenterally within 2 days