Official Title

Metabolic Effects of Subchronic Dopamine D2 Receptor Blockade by Antipsychotic Drugs in Healthy Humans
  • Phase

  • Study Type

  • Status

    Completed No Results Posted
  • Study Participants

We hypothesized that short-term treatment with AP drugs induces insulin resistance through a mechanistic route that is independent of weight gain and that atypical drugs exert stronger effects than typical compounds in this respect. We therefore treated healthy non-obese men with olanzapine (atypical AP) or haloperidol (typical AP) for 8 days, and studied the impact of these interventions on glucose and lipid metabolism by hyperinsulinemic euglycemic clamp, isotope dilution technology and indirect calorimetry.
Study Started
May 31
Primary Completion
Dec 31
Study Completion
Dec 31
Last Update
Feb 28

Drug olanzapine

olanzapine 10 mg/day for 8 days

  • Other names: Zyprexa

Drug Haloperidol

haloperidol 3 mg/day for 8 days

1 Active Comparator

Healthy men

2 Active Comparator

Healthy men with a positive family anamneses of schizophrenia


Inclusion Criteria:

Healthy men, with and without a positive family history of schizophrenia.
20 kg/m2 < BMI < 26 kg/m2
Age 20-40 years
Fasting plasma glucose < 6 mmo/L

Exclusion Criteria:

FPG > 6 mmol/L
BMI > 26 kg/m2
Psychiatric disorders and/or use of antipsychotic or antidepressants drugs at present or in the past.
Any significant chronic disease
Renal, hepatic or endocrine disease
Use of medication known to influence lipolysis and/or glucose metabolism
Total cholesterol > 7mmol/L and/or triglycerides > 2 mmol/L
Recent weight changes or attempts to loose weight (> 3 kg weight gain or loss, within the last 3 months)
Difficulties to insert an intravenous catheter
Smoking (current)
Severe claustrophobia (ventilated hood)
Recent blood donation (within the last 2 months)
Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year
Extensive sporting activities (more than 10 hours of exercise per week)
No Results Posted