Bone Disease in Severely Burned Children
Bone metabolism is adversely affected by severe burns in children for a period of time.
More closely monitored biochemical and radiologic parameters of bone and mineral metabolism will increase the likelihood of earlier detection of abnormalities and possible therapeutic interventions.
DEXA before discharge from acute admission and again one year post burn.
Two courses of IV Tetracycline(10mg./kg./day for two days)separated by a two week interval.
Bone biopsy to be taken in the operation room at the last skin grafting operation at the site of the iliac crest. A second bone biopsy will be taken one year later post discharge from the acute admission.
Inclusion Criteria: Children age 5-18 years old with at least 40% or more of their body burned. Exclusion Criteria: Anyone with a burn covering less than 40% of the body or whose burn covers the front of both hipbones. Anyone younger than 5 years old, anyone with a history of cancer or other metabolic disease process, or anyone who is pregnant or has an allergy to Tetracycline will also be excluded. Anyone who has participated in an investigational drug trial within the past 60 days from date of admission will be excluded from this study.