Omeprazole and Reflux Disease - Improvement of Clinical Outcome by Genotype-adjusted Dosing
Patients with gastroesophageal reflux disease (GERD) are either treated for 4 weeks with a standard dose (20mg) of omeprazole, a drug of first choice, or by an individualized dosing (20 or 60mg/day) according how fast the patient can metabolize (eliminate) the drug. The individual elimination capacity is genetically controlled and therefore all patients will be genotyped prior to therapy.
20 mg daily
20 vs. 60 mg daily, genotype dependent
Inclusion Criteria: Patients with GERD grade A and B (mild to moderate severe disease) diagnosed by routine endoscopy will be recruited in different clinical and ambulant centres of gastroenterology; written informed consent is obligatory Range of Age: 20-70 BMI: 20-30 Exclusion Criteria: Patients who are allergic to proton-pump inhibitors or show incompatibility Patients who have lactase deficiency Patients who have severe chronic disease Patients who participated in another study during the last three months Patients who are pregnant