PPI-Rebound-Trial. A Study of the Clinical Relevance of the Acid Rebound Phenomena
Lead SponsorUniversity Hospital Koge
The acid secretion in the stomach seems to increase after withdrawal of min. 8 wks of treatment with a PPI (protonpump inhibitor) It is unknown if this acid rebound phenomenon is of clinical significance. In a doubleblinded and placebocontrolled study healthy volunteers are randomized to treatment with placebo or PPI + placebo. Gastrointestinal symptoms are scored once a week and.
Inclusion Criteria: 18 years + Exclusion Criteria: Dyspepsia, heartburn og acid regurgitation within the preceeding 4 weeks Previous treatment with PPI og H2RA Previous contact to doctor or hospital because of dyspepsia or reflux Pregnancy or breast feeding