Suicide Prevention by Lithium - the Lithium Intervention Study
  • Phase

  • Study Type

  • Status

  • Intervention/Treatment

    lithium ...
  • Study Participants

The purpose of this study is to examine the proposed suicide preventive effects of lithium in a randomized controlled trial within a group of individuals with depressive disorders. The hypothesis being tested is that lithium treatment will significantly reduce the risk for another suicide attempt.
Several studies have shown that there is a significantly increased risk of suicide related mortality in patients with a positive history of suicide attempts. This study is the first prospective, randomized, double-blind, placebo controlled multi-center trial focussing on the proposed suicide preventive effects of lithium in patients with suicidal behavior but not suffering from bipolar disorder or recurrent major depressive disorder. Patients with a recent history of a suicide attempt are treated with lithium or placebo during a 12 month-period. The hypothesis is that lithium treatment will lead to a 50 % reduction of suicidal behavior.
Study Started
Jan 31
Study Completion
Jun 30
Last Update
Aug 23

Drug lithium

Drug placebo

1 Active Comparator

Lithium treatment

2 Placebo Comparator

Placebo treatment


Inclusion Criteria:

suicide attempt within 3 months prior to the first drug administration
occurrence of suicide attempt within the context of an affective spectrum disorder
minimum age of 18 years
ability to complete screening and baseline assessment
ability to understand and provide informed consent

Exclusion Criteria:

diagnosis of schizophrenia, borderline personality disorder, substance related disorders
indication for long-term lithium treatment
thyroid disease
pregnancy and lactation
No Results Posted