Trial of Efficacy and Safety of Sirolimus in Tuberous Sclerosis and LAM
A Trial of the Efficacy and Safety of Sirolimus(Rapamycin)Therapy for Renal Angiomyolipmoas in Patients With Tuberous Sclerosis Complex and Sporadic Lymphangioleiomyomatosis
  • Phase

    Phase 2
  • Study Type

  • Status

    Unknown status
  • Intervention/Treatment

    sirolimus ...
  • Study Participants

The purpose of this study is to determine the safety and efficacy of the mTOR inhibitor sirolimus as a treatment for renal angiomyolipomas in patients with tyberous sclerosis complex or sporadic lymphangioleiomyomatosis.
Inherited mutations of the TSC1 or TSC2 gene cause tuberous sclerosis while acquired (somatic) mutations of either gene are associated with sporadic lymphangioleiomyomatosis (LAM). Renal angiomyolipomas are a feature of both disorders. TSC1 and TSC2 regulate signalling through the mammalian target of rapamycin (mTOR) pathway. Inhibition of mTOR may result in a decrease in size of TSC 1/2 assciated lesions. We are treating patients with tuberous sclerosis or sporadic LAM with the mTOR inhibitor rapamycin in a non-randomised, open label pilot study of safety and efficacy. Change in size of renal angiomyolipomas is the primary end point
Study Started
Oct 31
Primary Completion
Sep 30
Study Completion
Sep 30
Last Update
Apr 30

Drug sirolimus

daily oral sirolimus with dosage individualised by trough blood levels

  • Other names: rapamune, rapamycin


Inclusion Criteria:

If female, documentation of negative pregnancy test prior to enrolment.
Participants, including males, must use an effective form of contraception, whilst taking sirolimus and for twelve weeks after stopping the drug
One or more renal angiomyolipomata of at least two centimetres or greater in largest diameter
Adequate renal function :glomerular filtration rate > 40 ml/min
Clinically definite diagnosis of tuberous sclerosis (modified Gomez criteria) or sporadic LAM (biopsy-proven or compatible high resolution chest CT scan and respiratory function tests.)
Signed and dated informed consent

Exclusion Criteria:

History of non-compliance or inability to give informed consent
Significant haematological or hepatic abnormality (i.e. transaminase levels > 150 i.u./L serum albumin < 30 g/L, haematocrit< 30%, platelets < 100,000/ mm3, adjusted absolute neutrophil count < 1,500/mm3, total WBC < 3,000/ mm3)
Greater than 1 g proteinuria daily
Multiple bilateral AMLs, where individual lesions cannot be distinguished
Renal haemorrhage within preceding year
In those who have had a renal haemorrhage, known conservatively managed renal aneurysm(s) greater than 10mm
Patients who have had embolisation for AML(s) within the preceding 6 months
Patients who are unable to walk 100 metres on the flat
Continuous requirement for supplemental oxygen
Patients who have had or are being considered for organ transplant
Uncontrolled hyperlipidaemia
Intercurrent infection at initiation of Sirolimus
Surgery within last 2 months
Pregnant or lactating women
Use of an investigational drug within the last 30 days
Change in anti epileptic drug medication within the last 3 months
Likely to need vaccination e.g. for travel during the course of the trial (except for influenza vaccine in patients with LAM)
Current usage of strong inhibitors of CYP3AE ( such as ketoconazole, voriconazole, itraconazole, tilithromycin or clarithromycin) or strong inducers (such as rifampicin or rifabutin)
No Results Posted