A Phase II Clinical Study of Lidocain Pertubation as Treatment for Couples With Unexplained Infertility
A Randomised, Open, Controlled, Parallel Group, Multi-Centre Phase II Clinical Study of Lidocain Pertubation as Treatment for Couples With Unexplained Infertility
The study tested the hypothesis that a pertubation with a lidocain solution will enhance pregnancy rate.
In a prospective study, patients were randomized during a clomiphene citrate stimulated cycle to either pertubation with low-dose lidocain or no pertubation before insemination.
Inclusion Criteria: Female, 20-40 years of age, If presence of peritoneal endometriosis they must be of minimal or mild without adhesions (verified by laparoscopy), Normal menstruation cycle, Male partner 20-70 years of age, Male partner, Normal sperm sample within 5 years (>20x106/mL, total sperm count >30x106, normal morphology 5%), Duration of infertility more than one year, Signed informed consent Exclusion Criteria: Treatment with NSAID, corticosteroids or other drugs, which can cause an increased risk of infection, Clinical signs of PID, Known hypersensitivity to local anesthetics, Non-patent fallopian tubes, Pathological uterine cavity, Pathological PCT, myoma > 2 cm diameter, Any disease or laboratory finding considered of importance by the investigator not to include the patient