Use of Erythromycin in Mustard-Induced Bronchiolitis
Low-Dose Long-Term Prescription of Erythromycin in Mustard-Induced Bronchiolitis Obliterans
  • Phase

    Phase 4
  • Study Type

  • Status

    Completed No Results Posted
  • Study Participants

We looked for the effectiveness of low-dose long-term prescription of erythromycin in mustard-induced bronchiolitis obliterans
Study Started
Aug 21
Last Update
Nov 05

Drug Erythromycin


Inclusion Criteria:

Documented chemical exposure
Clinical, spirometric and radiological findings were compatible with BO on High Resolution Computed Tomography (HRCT)
Non-responsiveness to high dose bronchodilator therapy

Exclusion Criteria:

Radiographic evidence of pneumonia, active tuberculosis, lung carcinoma, or an infection that necessitated the use of an antibiotic
History of cigarette smoking and occupational exposure to toxic agents of hypersensitivity to macrolides
History of treatment with a systemic antibiotic within 7 days before the start of the study
Any investigational medicine within 4 weeks of the study
History of antibiotic injection within 6 weeks before the study
Concomitant Theophylline or Carbamazepine, unless their serum concentrations were regularly monitored
Patients who were in the exacerbation phase of their respiratory complications
Need to use medications interact with macrolides such as Digoxin, Theophylline and Carbamazepine
Systemic antibiotics
Systemic Corticosteroids
Admission to the hospital
Abnormal kidney or liver function
No Results Posted