Comparison of Vasopressin and Other Pressors in Septic Shock
Comparative Prospective Study of Vasopressin and Catecholamine in Septic Shock
  • Phase

    Phase 2/Phase 3
  • Study Type

  • Status

    Completed No Results Posted
  • Study Participants

The purpose of this study is to compare the classical tactics in the treatment of septic shock (dopamine, noradrenalin and dobutamine) to the use of vasopressin as first choice pressor.

Vasopressin seems to be an interesting alternative in the treatment of septic shock. To this date, available studies have showed that it could correct hyperkinetic syndrome and vasoplegia in septic shocks without noticeable side effect. It as been demonstrated that vasopressin improves renal function, as no effect on digestive organs and as no metabolic effect.
Study Started
Jul 31
Last Update
May 29

Drug vasopressin


Inclusion Criteria:

Legally major patient presenting a septic shock.

The time window between beginning of symptoms and onset of treatment is established at 12 hours.

The patient must be intubated and mechanically ventilated.

Patient presenting a mean arterial blood pressure of less than 60 mm Hg after adequate fluid resuscitation (at least 1 L of colloid or crystalloid) and 10 ug/Kg/min of dopamine.

Patient presenting a cardiac index of at least 3 L/min/m2

Exclusion Criteria:

Shock other than septic
cardiac hypokinesia
a pre-existing organic renal failure that needs hemodyalisis
oesophagal or gastric phatology that would lead to a naso-gastric tube contraindication
No Results Posted