Prophylactic Antibiotics on Urethral Catheter Withdrawal
Use of Antibiotic Prophylaxis on Urethral Catheter Withdrawal: A Randomized Double-Blind Placebo-Controlled Trial
Lead SponsorSt. Antonius Hospital, Nieuwegein
StatusCompleted No Results Posted
Indication/ConditionUrinary Tract Infection Bacteriuria
Intervention/Treatmentsulfamethoxazole ciprofloxacin trimethoprim ...
Urinary-tract infection (UTI) is the most common type of hospital-acquired infection (30% of all). The purpose of this study is to determine whether antibiotic prophylaxis for urinary catheter removal is useful at preventing catheter-associated urinary-tract infection.
Urinary-tract infection (UTI) is the most common type of hospital-acquired infection (30% of all). The researchers undertake a double-blind, placebo-controlled trial to assess the efficacy of single-dose therapy of trimethoprim-sulfamethoxazole or ciprofloxacin, versus placebo therapy in selected groups of surgical patients who had bladder drainage scheduled to last longer than 3 days.
Inclusion Criteria: Urethral catheter in situ for at least 3 days (72h) Exclusion Criteria: Pregnancy Impaired renal or hepatic function (serum creatinine > 150 mmol/l, serum transaminases > 75 IU/l) Fever Symptomatic urinary tract infection Antibiotic use ≤ 48 hours before urinary catheter removal Allergy to trimethoprim-sulfamethoxazole or ciprofloxacin Urologic pathology