Vertex   Report issue

Contributed to NME For profit Phase 1 Phase 2 Phase 3 Phase 4
Founded: Boston MA United States (1989)
Status: Acquired by Henry Schein, Inc (1995) → now AbbVie (2019)

Organization Overview

First Clinical Trial
1998
NCT00003847
First Marketed Drug
2011
telaprevir (incivek)
First NDA Approval
2011
telaprevir (incivek)
Last Known Activity
2023

Timeline

NOW
  • Now

Mergers & Acquisitions

Historical Acquisition Tree

Alternative names

Veratex | Vertex Pharmaceutical Incorporated | Vertex Pharmaceuticals Incorporated | VERTEX PHARMS | VERTEX PHARMS INC

Active Ingredients

Marketed Drugs (5)

elexacaftor (Trifakta) (2019 NDA)

ivacaftor (Kalydeco) (2015 NDA)

lumacaftor (Orkambi) (NDA)

telaprevir (incivek) (2011 NDA)

tezacaftor (Trifakta) (2018 NDA)

Drugs in Phase 4 Trials (5)

Key: Vertex (3) Acquired (2)

interferon alpha-2b (Intron-A) (28 trials)

ivacaftor (Kalydeco) (100 trials)

lumacaftor (Orkambi) (24 trials)

ribavirin (virazole) (30 trials)

telaprevir (incivek) (39 trials)

Drugs in Phase 3 Trials (12)

acetaminophen (tylenol) (5 trials)

ctx001 (5 trials)

decernotinib (6 trials)

deutivacaftor (6 trials)

elexacaftor (Trifakta) (22 trials)

hydrocodone (hycodan) (5 trials)

tezacaftor (Trifakta) (49 trials)

vitamin d3 (1 trial)

vx-121 (8 trials)

vx-210 (1 trial)

vx-548 (10 trials)

vx-659 (6 trials)

Drugs in Phase 2 Trials (31)

Key: Vertex (26) Acquired (5)

allogeneic pancreatic islet cells (1 trial)

avn-944 (3 trials)

cethrin (1 trial)

ctp-656 (4 trials)

cyclosporine (sandimmune) (2 trials)

daclatasvir (daklinza) (1 trial)

doxorubicin (Doxil) (2 trials)

lomibuvir (5 trials)

mmpd (1 trial)

p-1037 (1 trial)

pec-01 cells (3 trials)

pregabalin (lyrica) (1 trial)

sodium chloride (3 trials)

sofosbuvir (sovaldi) (1 trial)

tacrolimus (prograf) (2 trials)

vch-759 (1 trial)

vctx211 (1 trial)

vincristine (oncovin) (1 trial)

vx-135 (3 trials)

vx-147 (1 trial)

vx-150 (4 trials)

vx-152 (1 trial)

vx-371 (2 trials)

vx-440 (2 trials)

vx-702 (2 trials)

vx 710 (1 trial)

vx-765 (3 trials)

vx-787 (1 trial)

vx-814 (1 trial)

vx-864 (2 trials)

vx-880 (1 trial)

Drugs in Phase 1 Trials (26)

Key: Vertex (24) Acquired (2)

als-002158 (1 trial)

als-002200 (1 trial)

buprenorphine (1 trial)

carboplatin (paraplatin) (2 trials)

ciprofloxacin (cipro) (2 trials)

cisplatin (platinol) (2 trials)

digoxin (lanoxin) (1 trial)

etoposide (vepesid) (1 trial)

gemcitabine (gemzar) (2 trials)

itraconazole (sporanox) (1 trial)

methadone (methadose) (1 trial)

methylprednisolone (medrol) (1 trial)

midazolam (versed) (1 trial)

moxifloxacin (avelox) (2 trials)

naloxone (narcan) (1 trial)

omeprazole (prilosec) (1 trial)

prednisone (meticorten) (1 trial)

raltegravir (isentress) (1 trial)

rifampin (3 trials)

vch-916 (1 trial)

vctx210a (1 trial)

vx-522 (1 trial)

vx-803 (1 trial)

vx-970 (1 trial)

vx-984 (1 trial)

vx-985 (1 trial)

Drugs in Other Trials (1)

bosutinib (bosulif) (1 trial)

Indications

Approved Indications


 

Cystic Fibrosis

Hepatitis C, Chronic

Experimental Indications (Clinical Trials, Phases 1-4)


 

Acute Pain (Phase 2)

alpha 1-Antitrypsin Deficiency (Phase 2)

Anemia, Sickle Cell (Phase 2)

Arthritis (Phase 3)

Arthritis, Rheumatoid (Phase 3)

beta-Thalassemia (Phase 2)

Bronchitis (Phase 2)

Bronchitis, Chronic (Phase 2)

Carcinoma (Phase 3)

Carcinoma, Hepatocellular (Phase 3)

Ciliary Motility Disorders (Phase 2)

Communicable Diseases (Phase 3)

Cystic Fibrosis (Phase 4)

Disease Progression (Phase 2)

Dyskinesias (Phase 2)

Epilepsies, Partial (Phase 2)

Epilepsy (Phase 2)

Fibrosis (Phase 4)

Genetic Diseases, Inborn (Phase 2)

Glomerulosclerosis, Focal Segmental (Phase 2)

Hematologic Diseases (Phase 2)

Hemoglobinopathies (Phase 2)

Hemophilia A (Phase 1)

Hepatic Insufficiency (Phase 1)

Hepatitis (Phase 4)

Hepatitis A (Phase 4)

Hepatitis C (Phase 4)

Hepatitis C, Chronic (Phase 4)

Hepatitis, Chronic (Phase 3)

Infections (Phase 3)

Influenza, Human (Phase 2)

Kartagener Syndrome (Phase 2)

Leukemia (Phase 1)

Liver Diseases (Phase 1)

Liver Failure (Phase 1)

Lung Diseases (Phase 3)

Lung Diseases, Obstructive (Phase 2)

Lung Neoplasms (Phase 2)

Lymphoma (Phase 1)

Multiple Myeloma (Phase 1)

Neoplasms (Phase 1)

Opioid-Related Disorders (Phase 1)

Osteoarthritis (Phase 2)

Osteoarthritis, Knee (Phase 2)

Pancreatic Neoplasms (Phase 2)

Psoriasis (Phase 2)

Pulmonary Disease, Chronic Obstructive (Phase 2)

Small Cell Lung Carcinoma (Phase 2)

Small Fiber Neuropathy (Phase 2)

Spinal Cord Injuries (Phase 3)

Thalassemia (Phase 2)

Virus Diseases (Phase 3)

Waldenstrom Macroglobulinemia (Phase 1)

Wounds and Injuries (Phase 3)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 208
  • # of Trial APIs: 75