Organization Overview
Historical Acquisition Tree
Alternative names
Key: Shire (24) Acquired (6)
acetaminophen (tylenol) (1986)
amphetamine (Adderall) (2001)
anagrelide (agrylin) (1997 NDA)
butalbital (fiornal) (1986)
caffeine (1986)
carbamazepine (tegretol) (1997)
dextroamphetamine (Dexedrine) (2001)
furazolidone (furoxone) (1958 NDA)
guanfacine (tenex) (2009)
histrelin (supprelin) (1991)
hydroflumethiazide (saluron) (1959 NDA)
icatibant (firazyr) (2011 NDA)
idursulfase (elaprase) (2006 NDA)
imiglucerase (cerezyme) (2010)
lanthanum (2014 NDA)
levodopa (larodopa) (1970)
lifitegrast (xiidra) (2016 NDA)
lisdexamfetamine (vyvanse) (2017)
mesalamine (rowasa) (1993)
methantheline bromide (banthine) (1951 NDA)
midodrine (proamatine) (1996 NDA)
moricizine (ethmozine) (1990 NDA)
nitrofural (1945)
phendimetrazine (plegine) (1981)
phentermine (wyamine) (1982)
propantheline bromide (pro-banthine) (1953 NDA)
prucalopride succinate (motegrity) (2018 NDA)
reserpine (serpasil) (1960)
tetracycline (tetrex) (1977)
uracil mustard (1962)
Key: Shire (17) Acquired (43)
agalsidase alfa (Replagal) (9 trials)
albumin (Human) (Plasbumin) (6 trials)
alpha-1 antitrypsin (Prolastin) (11 trials)
amino acids (Freamine) (1 trial)
amphetamine (Adderall) (19 trials)
amphotericin b (fungizone) (4 trials)
anagrelide (agrylin) (7 trials)
antihemophilic factor viii human (Hemofil M) (8 trials)
antihemophilic factor viii (Recombinant) (Adynovate) (33 trials)
atomoxetine (strattera) (5 trials)
C1 Esterase Inhibitor (Human) (Cinryze) (18 trials)
carbamazepine (tegretol) (3 trials)
ceftazidime (fortaz) (1 trial)
drotrecogin alfa, activated (Xigris) (3 trials)
eflornithine (ornidyl) (1 trial)
esmolol (brevibloc) (4 trials)
glycopyrronium (robinul) (1 trial)
guanfacine (tenex) (25 trials)
human coagulation factor ix (Mononine) (3 trials)
human factor ix complex (prothrombin complex concentrate) (Bebulin) (1 trial)
human fibrin (Tisseel) (23 trials)
hyaluronidase (human recombinant) (Hylenex) (16 trials)
icodextrin (Extraneal) (7 trials)
idursulfase (elaprase) (10 trials)
imiglucerase (cerezyme) (11 trials)
immune globulin (human) (Gamastan) (29 trials)
lifitegrast (xiidra) (10 trials)
lisdexamfetamine (vyvanse) (74 trials)
mesalamine (rowasa) (18 trials)
methylphenidate (ritalin) (9 trials)
metoprolol (lopressor) (1 trial)
midodrine (proamatine) (6 trials)
pioglitazone (actos) (2 trials)
polyethylene glycol (2 trials)
propofol (diprivan) (6 trials)
remifentanil (ultiva) (1 trial)
rocuronium (zemuron) (1 trial)
ropivacaine (naropin) (2 trials)
sevelamer (renagel) (5 trials)
sevoflurane (ultane) (6 trials)
soybean oil (Intralipid) (4 trials)
Key: Shire (21) Acquired (60)
acellular pertussis vaccine (including diptheria and tetanus toxoids) (Tripedia) (1 trial)
acetaminophen (tylenol) (2 trials)
adalimumab (humira) (3 trials)
allogenic neonatal dermal fibroblasts (1 trial)
antihemophilic factor viii (Recombinant), porcine sequence (Obizur) (5 trials)
anti-inhibitor coagulant complex (activated prothrombin complex concentrate) (Autoplex-T) (2 trials)
aprotinin (trasylol) (3 trials)
asparaginase (elspar) (1 trial)
autologous cd34+ cells (2 trials)
budesonide (rhinocort) (6 trials)
cariprazine (vraylar) (3 trials)
ciprofloxacin (cipro) (3 trials)
citalopram (celexa) (3 trials)
clofarabine (clolar) (2 trials)
coagulation factor viia (recombinant) (NovoSevenRT) (1 trial)
cyclosporine (sandimmune) (1 trial)
cytarabine (cytosar-u) (8 trials)
dasatinib (sprycel) (2 trials)
daunorubicin (cerubidine) (2 trials)
dexmedetomidine (precedex) (1 trial)
dexrazoxane (zinecard) (1 trial)
doxorubicin (Doxil) (5 trials)
duloxetine (Cymbalta) (4 trials)
ecallantide (Kalbitor) (10 trials)
erwinia asparaginase (Erwinaze) (2 trials)
escitalopram (lexapro) (4 trials)
etanercept (enbrel) (2 trials)
etoposide (vepesid) (3 trials)
foscarnet (foscavir) (1 trial)
galantamine (reminyl) (1 trial)
ganciclovir (cytovene) (2 trials)
haemophilus influenzae type b conjugate vaccine (HibTITER) (1 trial)
irinotecan (Camptosar) (6 trials)
lanadelumab (takhzyro) (13 trials)
levobupivacaine (chirocaine) (1 trial)
maralixibat (LIVMARLI) (1 trial)
maribavir (Livtencity) (9 trials)
Meningococcal (Groups A, C, Y, W) Conjugate Vaccine (MenQuadfi) (1 trial)
mercaptopurine (purinethol) (4 trials)
methylprednisolone (medrol) (1 trial)
Monovalent group C meningococcal vaccine (Menomune-C) (1 trial)
nelarabine (arranon) (1 trial)
pegaspargase (oncaspar) (8 trials)
phosphate-buffered saline (3 trials)
posaconazole (noxafil) (1 trial)
povidone-iodine (betadine) (2 trials)
rabies vaccine (purified chick embryo cell vaccine) (RabAvert) (1 trial)
ross river virus vaccine (2 trials)
sertraline (zoloft) (4 trials)
teduglutide (gattex kit) (23 trials)
telmisartan (micardis) (1 trial)
thrombin (bovine) (Thrombostat) (2 trials)
tranexamic acid (cyklokapron) (2 trials)
valganciclovir (Valcyte) (2 trials)
venlafaxine (effexor) (5 trials)
Key: Shire (22) Acquired (43)
acetylcysteine (mucomyst) (1 trial)
amiodarone (cordarone) (2 trials)
armodafinil (nuvigil) (1 trial)
autologous mononuclear stem cell (1 trial)
bevacizumab (avastin) (1 trial)
calcipotriene (dovonex) (1 trial)
carboplatin (paraplatin) (1 trial)
cisplatin (platinol) (1 trial)
fibrinogen (human) (RiaSTAP) (1 trial)
fluorouracil (efudex) (5 trials)
gemcitabine (gemzar) (2 trials)
Hydroxymethylfurfural (3 trials)
interferon alpha-2b (Intron-A) (1 trial)
lansoprazole (prevacid) (1 trial)
multivalent recombinant ospa lyme borreliosis vaccine (1 trial)
oxaliplatin (eloxatin) (1 trial)
panitumumab (vectibix) (1 trial)
Key: Shire (14) Acquired (34)
afamelanotide (Scenesse) (1 trial)
anti-macrophage migration inhibitory factor antibody (2 trials)
butyrlcholinesterase, human (Recombinant) (Protexia) (2 trials)
calcitriol (rocaltrol) (1 trial)
ceftriaxone (rocephin) (1 trial)
iron sucrose (venofer) (1 trial)
mannose binding lectin (4 trials)
metronidazole (flagyl) (1 trial)
moxifloxacin (avelox) (3 trials)
omeprazole (prilosec) (1 trial)
procaine benzylpenicillin (novocaine) (1 trial)
Key: Shire (1) Acquired (6)
Adenocarcinoma (Phase 2)
Adrenal Insufficiency (Phase 3)
Aggression (Phase 4)
Alagille Syndrome (Phase 2)
alpha 1-Antitrypsin Deficiency (Phase 4)
Alzheimer Disease (Phase 3)
Anemia (Phase 4)
Anemia, Sickle Cell (Phase 2)
Angioedema (Phase 4)
Angioedemas, Hereditary (Phase 4)
Anxiety Disorders (Phase 4)
Anxiety, Separation (Phase 2)
Arteriovenous Fistula (Phase 2)
Ataxia (Phase 1)
Autism Spectrum Disorder (Phase 4)
Autistic Disorder (Phase 4)
beta-Thalassemia (Phase 2)
Bile Duct Neoplasms (Phase 2)
Biliary Tract Neoplasms (Phase 2)
Binge-Eating Disorder (Phase 3)
Bipolar Disorder (Phase 4)
Brain Injuries (Phase 4)
Brain Injuries, Traumatic (Phase 4)
Bronchopulmonary Dysplasia (Phase 3)
Bulimia (Phase 3)
Calciphylaxis (Phase 1)
Carcinoma (Phase 2)
Carcinoma, Ductal (Phase 2)
Carcinoma, Hepatocellular (Phase 2)
Carcinoma, Squamous Cell (Phase 2)
Cerebellar Ataxia (Phase 1)
Cholangiocarcinoma (Phase 2)
Cholangitis (Phase 2)
Cholangitis, Sclerosing (Phase 2)
Cholestasis (Phase 3)
Cholestasis, Intrahepatic (Phase 3)
Clostridium Infections (Phase 2)
Cognitive Dysfunction (Phase 4)
Colitis (Phase 4)
Colitis, Ulcerative (Phase 4)
Communicable Diseases (Phase 2)
Conjunctivitis (Phase 3)
Conjunctivitis, Allergic (Phase 2)
Conjunctivitis, Bacterial (Phase 3)
Conjunctivitis, Inclusion (Phase 3)
Conjunctivitis, Viral (Phase 2)
Constipation (Phase 4)
Crohn Disease (Phase 3)
Cytomegalovirus Infections (Phase 3)
Dementia (Phase 3)
Depression (Phase 4)
Depressive Disorder (Phase 4)
Depressive Disorder, Major (Phase 4)
Disease (Phase 4)
Diverticulitis (Phase 3)
Dry Eye Syndromes (Phase 4)
Emphysema (Phase 4)
Eosinophilic Esophagitis (Phase 3)
Epidermolysis Bullosa (Phase 3)
Esophageal Squamous Cell Carcinoma (Phase 2)
Esophagitis (Phase 3)
Esophagitis, Peptic (Phase 2)
Eye Diseases (Phase 4)
Fabry Disease (Phase 3)
Familial Mediterranean Fever (Phase 2)
Fatigue (Phase 4)
Fatigue Syndrome, Chronic (Phase 4)
Fatty Liver (Phase 2)
Feeding and Eating Disorders (Phase 3)
Fibrosis (Phase 2)
Fistula (Phase 2)
Friedreich Ataxia (Phase 1)
Gastroesophageal Reflux (Phase 2)
Gaucher Disease (Phase 4)
Glaucoma (Phase 1)
Glaucoma, Open-Angle (Phase 1)
Glucose Intolerance (Phase 4)
Headache (Phase 2)
Hemophilia A (Phase 3)
Hemophilia B (Phase 4)
Hemorrhage (Phase 3)
Hemosiderosis (Phase 2)
Hereditary Autoinflammatory Diseases (Phase 2)
Hirsutism (Phase 4)
Hyperkinesis (Phase 4)
Hyperphosphatemia (Phase 3)
Hypertension (Phase 1)
Hypocalcemia (Phase 2)
Hypoparathyroidism (Phase 4)
Hypotension (Phase 4)
Hypotension, Orthostatic (Phase 4)
Immunologic Deficiency Syndromes (Phase 4)
Infections (Phase 3)
Inflammation (Phase 4)
Iron Metabolism Disorders (Phase 2)
Iron Overload (Phase 2)
Irritable Bowel Syndrome (Phase 3)
Keratoconjunctivitis (Phase 4)
Keratoconjunctivitis Sicca (Phase 4)
Kidney Diseases (Phase 4)
Kidney Failure, Chronic (Phase 4)
Leukemia (Phase 3)
Leukemia, Lymphoid (Phase 3)
Leukemia, Myeloid (Phase 2)
Leukodystrophy, Metachromatic (Phase 2)
Liver Cirrhosis (Phase 2)
Liver Cirrhosis, Biliary (Phase 2)
Liver Diseases (Phase 2)
Lung Diseases (Phase 4)
Lung Diseases, Obstructive (Phase 4)
Lymphoma (Phase 3)
Metabolic Diseases (Phase 2)
Migraine Disorders (Phase 2)
Mucopolysaccharidoses (Phase 4)
Mucopolysaccharidosis II (Phase 4)
Mucopolysaccharidosis III (Phase 2)
Nervous System Diseases (Phase 3)
Non-alcoholic Fatty Liver Disease (Phase 2)
Obesity (Phase 4)
Ocular Hypertension (Phase 1)
Osteoporosis (Phase 3)
Osteoporosis, Postmenopausal (Phase 3)
Otitis (Phase 3)
Otitis Externa (Phase 3)
Otomycosis (Phase 3)
Overweight (Phase 1)
Pancreatic Neoplasms (Phase 3)
Peripheral Arterial Disease (Phase 2)
Phobia, Social (Phase 2)
Phobic Disorders (Phase 2)
Pneumonia (Phase 1)
Polyradiculoneuropathy (Phase 3)
Premature Birth (Phase 3)
Pruritus (Phase 2)
Pulmonary Disease, Chronic Obstructive (Phase 4)
Purpura (Phase 3)
Purpura, Thrombocytopenic (Phase 3)
Purpura, Thrombotic Thrombocytopenic (Phase 3)
Recurrence (Phase 3)
Renal Insufficiency (Phase 4)
Renal Insufficiency, Chronic (Phase 4)
Retinal Diseases (Phase 2)
Retinopathy of Prematurity (Phase 3)
Schizophrenia (Phase 3)
Short Bowel Syndrome (Phase 3)
Sleep Deprivation (Phase 2)
Sleep Wake Disorders (Phase 4)
Status Epilepticus (Phase 3)
Stress Disorders, Traumatic (Phase 4)
Stress, Psychological (Phase 3)
Substance Withdrawal Syndrome (Phase 2)
Syndrome (Phase 4)
Thalassemia (Phase 2)
Thrombocythemia, Essential (Phase 4)
Thrombocytosis (Phase 4)
Tic Disorders (Phase 4)
Tics (Phase 4)
Tourette Syndrome (Phase 4)
Ulcer (Phase 4)
von Willebrand Diseases (Phase 3)
Wounds and Injuries (Phase 4)
