Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Neoplasm Proteins » Tumor Suppressor Proteins
Description
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development. MeSH
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Subtype Terms (28)
Adenomatous Polyposis Coli Protein
BRCA1 Protein
56 drugs (39 approved, 17 experimental)
BRCA2 Protein
1 approved drug
Cyclin-Dependent Kinase Inhibitor Proteins
Promyelocytic Leukemia Protein
PTEN Phosphohydrolase
3 drugs (2 approved, 1 experimental)
Retinoblastoma-Like Protein p107
Tuberous Sclerosis Complex 1 Protein
Tuberous Sclerosis Complex 2 Protein
Tumor Suppressor Protein p14ARF
Tumor Suppressor Protein p53
13 drugs (10 approved, 3 experimental)
Von Hippel-Lindau Tumor Suppressor Protein
WT1 Proteins
3 drugs (2 approved, 1 experimental)
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